Table 2.
Physiological parameters in mice.
| MRC1 WT | MRC1 KO | |||||
|---|---|---|---|---|---|---|
| Group | SHAM | I/R | I/R + AOSC | SHAM | I/R | I/R + AOSC |
| UO (ml) | 0.79 ± 0.07 | 1.49 ± 0.13* | 0.96 ± 0.15*# | 0.86 ± 0.12 | 1.13 ± 0.17 | 1.02 ± 0.17 |
| PCr (μmol/L) | 11.9 ± 0.9 | 132.1 ± 29.3* | 53.4 ± 15.2*# | 12.1 ± 0.5 | 81.5 ± 23.2& # | 77.4 ± 23.6& |
| Posm (mOsm/kg·H2O) | 309.8 ± 8.2 | 305.0 ± 2.8 | 306.8 ± 8.8 | 309.2 ± 6.0 | 301.7 ± 5.4 | 295.0 ± 6.9 |
| Uosm (mOsm/kg·H2O) | 3297 ± 192 | 764 ± 72* | 1581 ± 273*# | 3058 ± 316 | 1039 ± 43 | 1626 ± 384 |
| U-Alb (μg/24 h) | 2.4 ± 0.9 | 127.2 ± 10.2* | 36.3 ± 8.9*# | 2.0 ± 0.5 | 54.0 ± 11.8& # | 43.8 ± 10.9& |
| P-Na+ (mmol/L) | 154.1 ± 0.5 | 155.1 ± 0.8 | 156.4 ± 1.2 | 156.6 ± 1.2 | 155.1 ± 0.9 | 156.8 ± 0.9 |
| P-K+ (mmol/L) | 3.29 ± 0.10 | 5.27 ± 0.74* | 3.92 ± 0.36# | 3.65 ± 0.29 | 5.23 ± 0.69& | 4.59 ± 0.25 |
| FENa (%) | 0.03 ± 0.006 | 0.28 ± 0.03* | 0.09 ± 0.02*# | 0.03 ± 0.002 | 0.12 ± 0.02& # | 0.11 ± 0.03& |
MRC1 WT MRC1 wild type, MRC1 KO MRC1 knockout, SHAM sham-operated group, I/R renal ischemia-reperfusion group, I/R + AOSC I/R group with AOSC, UO urine output, PCr plasma creatinine, Posm plasma osmolality, Uosm urine osmolality, U-Alb urine albumin, P-Na+ plasma sodium, P-K+ plasma potassium, FENa fractional excretion of sodium.
*P < 0.05 compared with WT-SHAM. #P < 0.05 compared with WT-I/R. &P < 0.05 compared with KO-SHAM. n = 4–6 in each group.