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. 2025 Aug 22;16:7848. doi: 10.1038/s41467-025-62848-x

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© The Author(s) 2025

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Fig. 4 — Panel (A): Depiction of the four subclusters identified in the Dysregulated cluster named Cluster 3 (orange), Cluster 4 (brown), Cluster 5 (green), and Cluster 6 (yellow) on the 3-dimensional UMAP. Panel (B): Mean standardised values of protein biomarkers (left panel) and continuous clinical variables (right panel) in Cluster 3. Panel (C): Mean standardised values of protein biomarkers (left panel) and continuous clinical variables (right panel) in Cluster 4. Panel (D): Mean standardised values of protein biomarkers (left panel) and continuous clinical variables (right panel) in Cluster 5. Panel (E): Mean standardised values of protein biomarkers (left panel) and continuous clinical variables (right panel) in Cluster 4. Values were standardised to the mean values of the entire cohort for each variable in Panels B–E. ALT Alanine Aminotransferase, AST Aspartate Aminotransferase, BUN Blood Urea Nitrogen; CRP C-reactive protein; DBP Diastolic blood pressure; FLT-3 ligand Fms-related tyrosine kinase 3 ligand; GCSF Granulocyte Colony-Stimulating Factor; GMCSF Granulocyte-Macrophage Colony-Stimulating Factor; IL Interleukin; IP-10 Interferon Gamma-Induced Protein 10; MCP Monocyte Chemoattractant Protein; MIP Macrophage Inflammatory Protein; NGAL Neutrophil Gelatinase-Associated Lipocalin; NLR Neutrophil:Lymphocyte; PDL-1 Programmed Death-Ligand 1; RDW Red Cell Distribution Width; SBP Systolic Blood Pressure; SF Ratio SpO₂/FiO₂; sTREM-1 Soluble Triggering Receptor Expressed on Myeloid Cells; TNF Tumour Necrosis Factor; TRAIL TNF-related apoptosis-inducing ligand; UMAPL Uniform Manifold Approximation and Projection; VCAM-1 Vascular Cell Adhesion Molecule-1; VEGF Vascular Endothelial Growth Factor; WBC White Blood Cell Count.