Table 2.
Univariate and multivariate Cox regression analysis of demographic characteristics, HLA subtype, and EGFR TKIs progression-free survival in HLA-A assessment cohort (n = 86).
| Factor | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Gender | 0.98 | 0.924 | - | - |
| Female vs. male | (0.58–1.64) | |||
| Age | 0.96 | 0.876 | - | - |
| ≥ 60 vs. <60 | (0.60–1.55) | |||
| Smoking status | 1.87 | 0.072 | 2.00 | 0.060 |
| Former/current smoker vs. Non-smoker | (0.93–3.74) | (0.97–4.10) | ||
| Histology | 0.75 | 0.435 | 0.87 | 0.715 |
| Adenocarcinoma vs. non-adenocarcinoma | (0.37–1.54) | (0.42–1.82) | ||
| Generation of EGFR TKIs | 0.48 | 0.018 | 0.36 | 0.005 |
| 2nd − 3rd generations vs. 1st generation | (0.26–0.89) | (0.18–0.74) | ||
| Liver metastasis | 2.15 | 0.013 | 2.98 | 0.002 |
| Presence vs. absence | (1.16–3.99) | (1.49–5.98) | ||
| HLA-A subtype in common EGFR mutation | 0.86 | 0.60 | - | - |
| Interested vs. non-interested | (0.53–1.40) | |||