Table 3.
Correlation between HLA-A subtypes (interested vs. non-interested) and TIME characteristic in overlapped data set (n = 49).
| Category | No. of Participants (n = 49) (%) |
Interested HLA-A (n = 22) (%) | Non-interested HLA-A (n = 27) (%) | p-value |
|---|---|---|---|---|
| Exon 19 del (n = 35) | ||||
| Inflammatory TIME | 6 (17.2) | 5 (26.4) | 1 (6.3) | 0.335 |
| Non-inflammatory TIME | 29 (82.8) | 14 (73.6) | 15 (93.7) | |
| Presence of intra-tumoral CD8 TILs | 13 (37.1) | 8 (42.2) | 5 (31.3) | 0.473 |
| Absence of intra-tumoral CD8 TILs | 22 (62.9) | 11 (57.8) | 11 (68.7) | |
| Exon 21 L858R (n = 14) | ||||
| Inflammatory TIME | 2 (14.3) | 0 (0.0) | 2 (18.2) | 1.000 |
| Non-inflammatory TIME | 12 (85.7) | 3 (100.0) | 9 (81.8) | |
| Presence of intra-tumoral CD8 TILs | 3 (21.4) | 2 (66.7) | 1 (9.1) | 0.108 |
| Absence of intra-tumoral CD8 TILs | 10 (71.4) | 1 (33.3) | 9 (81.8) | |
| Can’t interpreted data | 1 (7.2) | - | 1 (9.1) | |