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. 2025 Jul 23;17(7):e88631. doi: 10.7759/cureus.88631

Table 4. Summary of key referenced studies on the diagnosis and management of trigeminal nerve injuries.

DO: Distraction osteogenesis; BSSO: Bilateral sagittal split osteotomy; CBCT: Cone-beam computed tomography; IAN: Inferior alveolar nerve; PGA: Polyglycolic acid; QST: Qualitative sensory testing; MRCS: Medical Research Council Scale; MR: Magnetic resonance; VR: Virtual reality; 3D: Three-dimensional.

Author(s) Year Study Type Key Findings/Methodology
Jerjes et al. [2] 2010 Clinical study/review Identified risk factors for IAN and lingual nerve injuries during third molar removal.
Pogrel and Kaban [3] 1993 Review Analyzed causes and nature of IAN damage during root canal therapy.
Wijbenga et al. [6] 2009 Clinical study Compared neurosensory outcomes in DO vs. BSSO; highlighted differential recovery patterns.
Bagheri et al. [9] 2009 Clinical study/review Reviewed microsurgical repair outcomes in maxillofacial trauma-related trigeminal nerve injuries.
Van der Cruyssen et al. [15] 2023 Consensus statement Recommended QST and MRCS for diagnosis; QST and MR neurography for uncertain cases.
Schiavone and Ziccardi V [16] 2021 Literature review Provided a comprehensive synthesis of trigeminal nerve injuries in oral surgery.
Ziccardi and Steinberg MJ [17] 2007 Literature review Identified three-month non-recovery period as optimal threshold for considering microsurgery.
Ziccardi [18] 2011 Technique review Described microsurgical techniques including neurolysis, neurorrhaphy, and neuroma excision.
Nectow et al. [19] 2012 Review Discussed biomaterials (collagen, silicone, and PGA) and future strategies for nerve conduits.
Nath and Mackinnon [20] 2000 Review Discussed indications and limitations of nerve transfers for proximal nerve injuries.
Strauch [22] 2000 Review Evaluated use and limitations of nerve conduits in clinical and experimental repair.
Battiston et al. [23] 2000 Animal study Vein-muscle grafts enhanced nerve fiber density over six months in rat sciatic models.
Mosahebi et al. [28] 2003 Experimental study Fibronectin-enhanced alginate matrix improved Schwann cell viability and regeneration.
Brushart et al. [31] 2002 Animal study 20-Hz electrical stimulation post-suture enhanced motoneuron regeneration in rats.
Sarwar and Jabin [41] 2023 Review AI-enhanced CBCT improves nerve visualization and risk assessment.
Fang et al. [33] 2023 Methodology study Proposed soft tissue-driven planning to improve precision in craniofacial nerve surgery.
Nguyen et al. [42] 2023 Methodology study Developed 3D auto-segmentation tools for surgical wound planning in nerve repair.
Vizziello et al. [43] 2023 Feasibility study Demonstrated intra-body device communication for nerve monitoring and control.
Sadeghnejad et al. [44] 2019 Validation study Validated VR haptic simulation for training in trigeminal nerve microsurgery.