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. 2025 Jul 7;26(16):4072–4099. doi: 10.1038/s44319-025-00512-7

Reagents and tools table

Reagent/resource Reference or source Identifier or catalog number
Experimental models
C. elegans wild isolate var Bristol Caenorhabditis Genetics Center N2
wago-1(ok1074) I. deletion; presumed null Caenorhabditis Genetics Center RB1096
wago-3(pk1673) I. deletion; presumed null Caenorhabditis Genetics Center NL5117
wago-4(tm1019) II. deletion; presumed null Barstead et al, 2012 RFK22
hrde-1(tm1200) III. deletion; presumed null Caenorhabditis Genetics Center YY538
pei-1(ok1050) IV. deletion; presumed null Caenorhabditis Genetics Center RB1083
pei-2(xf270) V. deletion; presumed null Schreier et al, 2022 RFK1342
pgl-1(xf233[pgl-1::mTagRfp-t]) IV. Schreier et al, 2022 RFK1086
ttTi5605 II; unc-119(ed3) III; oxEx1578[eft-3p::gfp + Cbr-unc-119(+)]. Frøkjær-Jensen et al, 2012 EG6699
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II. This study RFK1305
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; him-5(e1490) V. This study RFK1622
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; pgl-1(xf233[pgl-1::mTagRfp-t]) IV. This study RFK1527
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; wago-1(ok1074) I. This study RFK1513
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; wago-3(pk1673) I. This study RFK1520
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; wago-4(tm1019) II. This study RFK1515
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; hrde-1(tm1200) III. This study RFK1494
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; znfx-1(xf347) II. This study RFK1615
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; pgl-1(xf233[pgl-1::mTagRfp-t]) IV; him-5(e1490) V. This study RFK1405
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; pgl-1(xf233[pgl-1::mTagRfp-t]) IV; him-5(e1490) V; wago-1(ok1074) I. This study RFK1512
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; pgl-1(xf233[pgl-1::mTagRfp-t]) IV; him-5(e1490) V; wago-3(pk1673) I. This study RFK1470
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; pgl-1(xf233[pgl-1::mTagRfp-t]) IV; him-5(e1490) V; wago-4(tm1019) II. This study RFK1514
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; pgl-1(xf233[pgl-1::mTagRfp-t]) IV; him-5(e1490) V; hrde-1(tm1200) III. This study RFK1473
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; pgl-1(xf233[pgl-1::mTagRfp-t]) IV; him-5(e1490) V; znfx-1(xf347) II. This study RFK1619
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; pgl-1(xf233[pgl-1::mTagRfp-t]) IV; him-5(e1490) V; pei-1(ok1050) IV. This study RFK1471
xfSi255[his-67p::gfp::his-67::tbb-2 3’UTR + Cbr-unc-119( + )] II; pgl-1(xf233[pgl-1::mTagRfp-t]) IV; him-5(e1490) V; pei-2(xf270) V. This study RFK1472
Recombinant DNA
Plasmid—Induces Mos1 transposition by injection. Addgene pCFJ601 - #34874
Plasmid—Negative selection, heat-shock inducible. Addgene pMA122 - #34873
Plasmid—Visual extra-chromosomal array marker. Red, nervous system, cytosolic. Addgene pGH8 - #19359
Plasmid—Visual extra-chromosomal array marker. Red, body wall muscle, cytosolic. Addgene pCFJ104 - #19328
Plasmid—Visual extra-chromosomal array marker. Red, pharynx, cytosolic. Addgene pCFJ90 - #19327
Plasmid—Multiple cloning site vector for MosSCI on locus ttTi5605 Addgene pCFJ350 - #34866
Plasmid—gfp::SEC::3xflag parental vector for CRISPR/Cas9 insertions Addgene pDD282 - #66823
Plasmid—[his-67p::gfp::his-67::tbb-2 3’UTR] insertion in pCFJ350 This study pRFK4197
Plasmid—Expression of Cas9 and sgRNA(F + E) without protospacer Schreier et al, 2022 pRFK2411
Plasmid—Expression of sgRNA(F + E) without protospacer Schreier et al, 2022 pRFK2412
Plasmid—Expression of Cas9 and unc-58 sgRNA1(F + E) Schreier et al, 2022 pRFK2588
Plasmid—Expression of znfx-1 sgRNA1(F + E) This study pRFK3358
Plasmid—Expression of znfx-2 sgRNA1(F + E) This study pRFK3359
Plasmid—Expression of znfx-3 sgRNA1(F + E) This study pRFK3360
Plasmid—Expression of znfx-4 sgRNA1(F + E) This study pRFK3361
Plasmid—Empty backbone for RNAi feeding experiments Addgene L4440 - #1654
Plasmid—gfp sequence from pDD282 inserted in L4440 This study pRK4103
Antibodies
Monoclonal mouse anti-GFP (B-2) Santa Cruz Biotechnology #sc-9996
Monoclonal rabbit β-Actin (D6A8) Cell Signaling Technology #8457
Anti-mouse IgG, HRP-linked antibody Cell Signaling Technology #7076
Anti-rabbit IgG, HRP-linked antibody Cell Signaling Technology #7074
Oligonucleotides and other sequence-based reagents
Protospacer sequence—ATC CAC GCA CAT GGT CAC TA Arribere et al, 2014 unc-58(e665) #1
Protospacer sequence—CCA CCT CAA CGT GAG GTT GG This study znfx-1(xf347) #1
Protospacer sequence—ATC CAT CGC GAT GCC CAT GG This study znfx-1(xf347) #2
Protospacer sequence—TAA TCT CAC CAA TGC TTC GG This study znfx-1(xf347) #3
Protospacer sequence—GAC ATC AGA TCG AAT GTT GG This study znfx-1(xf347) #4
attcttctcctttactcat LGC Biosearch Technologies gfp smFISH probe #1
gaggattgggacaactcca LGC Biosearch Technologies gfp smFISH probe #2
cgttgacgtctccgtcgag LGC Biosearch Technologies gfp smFISH probe #3
ccggagacggagaacttgt LGC Biosearch Technologies gfp smFISH probe #4
gtgagctttccgtaggtgg LGC Biosearch Technologies gfp smFISH probe #5
gtggtgcagatgaacttga LGC Biosearch Technologies gfp smFISH probe #6
catgggactgggagctttc LGC Biosearch Technologies gfp smFISH probe #7
aaggtggtgacgagggttg LGC Biosearch Technologies gfp smFISH probe #8
agaagcattggactccgta LGC Biosearch Technologies gfp smFISH probe #9
cttcatgtggtctgggtaa LGC Biosearch Technologies gfp smFISH probe #10
ttgtagagctcgtccattc LGC Biosearch Technologies gfp smFISH probe #11
ggcggacttgaagaagtcg LGC Biosearch Technologies gfp smFISH probe #12
tcttggacgtatccctctg LGC Biosearch Technologies gfp smFISH probe #13
cgtccttgaagaagatggt LGC Biosearch Technologies gfp smFISH probe #14
gcacgggtcttgtagtttc LGC Biosearch Technologies gfp smFISH probe #15
tgtctccctcgaacttgac LGC Biosearch Technologies gfp smFISH probe #16
gctcgatacggttgacgag LGC Biosearch Technologies gfp smFISH probe #17
tcctccttgaagtcgattc LGC Biosearch Technologies gfp smFISH probe #18
ttgtgtccgaggatgtttc LGC Biosearch Technologies gfp smFISH probe #19
gagttgtagttgtactcga LGC Biosearch Technologies gfp smFISH probe #20
gccatgatgtagacgttgt LGC Biosearch Technologies gfp smFISH probe #21
attccgttcttttgcttgt LGC Biosearch Technologies gfp smFISH probe #22
cggatcttgaagttgacct LGC Biosearch Technologies gfp smFISH probe #23
gatccgtcctcgatgttgt LGC Biosearch Technologies gfp smFISH probe #24
tagtggtcggcgagttgga LGC Biosearch Technologies gfp smFISH probe #25
ccgattggggtgttttgtt LGC Biosearch Technologies gfp smFISH probe #26
ttgtctgggaggaggactg LGC Biosearch Technologies gfp smFISH probe #27
gattgggtggagaggtagt LGC Biosearch Technologies gfp smFISH probe #28
gtttgggtccttggagagg LGC Biosearch Technologies gfp smFISH probe #29
gaccatgtggtcacgcttc LGC Biosearch Technologies gfp smFISH probe #30
cggcggtgacgaactcgag LGC Biosearch Technologies gfp smFISH probe #31
Chemicals, enzymes, and other reagents
4% Paraformaldehyde Sigma-Aldrich #441244
Deionized formamide Thermo Fisher Scientific #AM9342
Dextran sulfate Sigma-Aldrich #D4911
E. coli tRNA Roche #10109550001
Vanadyl ribonucleoside complex NEB BioLabs #S1402
Software
WormBase https://wormbase.org/ Harris et al, 2020; Sternberg et al, 2024; Davis et al, 2022
CRISPOR http://crispor.tefor.net Haeussler et al, 2016
Other
THUNDER Imager inverted widefield microscope Leica
BC43 spinning disk confocal microscope Andor
ChemiDoc XRS+ System Bio-Rad