Table 1.

The accession number of the SNPs and direct accessible links of the software/tools mentioned in the manuscript.

SNP IDs	Links
rs5743316	rs5743316 RefSNP Report - dbSNP - NCBI
rs199768900	rs199768900 RefSNP Report - dbSNP - NCBI
rs200214332	rs200214332 RefSNP Report - dbSNP - NCBI
rs201540925	rs201540925 RefSNP Report - dbSNP - NCBI
rs748141748	rs748141748 RefSNP Report - dbSNP - NCBI
rs752889035	rs752889035 RefSNP Report - dbSNP - NCBI
rs760275329	rs760275329 RefSNP Report - dbSNP - NCBI
rs768091235	rs768091235 RefSNP Report - dbSNP - NCBI

Software/Tools Used	Links
Meta-SNP	Meta-SNP - Meta-predictor of disease causing variants
Mutation Assessor	http://mutationassessor.org/v1
PANTHER	pantherdb.org
PredictSNP	PredictSNP: Predict SNP effect!
SNAP	SNAP (Screening for NonAcceptable Polymorphisms) | NGRL Manchester
PhD-SNAP	PhD-SNP: Predictor of human Deleterious Single Nucleotide Polymorphisms
SNPs&GO	SNPs&GO - Predicting disease associated variations using GO terms
I-Mutant	Welcome to I-Mutant2.0 Home Page
CUPSAT	CUPSAT
MUpro	Prediction of Protein Stability Changes upon Mutations
Align-GVGD	Use - Align GVGD
ConSurf	ConSurf | Evolutionary conservation profiles of proteins
NetSurfP 2.0	NetSurfP 2.0 - DTU Health Tech - Bioinformatic Services
CScape	CScape
CScape Somatic	CScape Somatic
HOPE	www3.cmbi.umcn.nl/hope/
STRING	STRING: functional protein association networks
Cytoscape	Cytoscape: An Open Source Platform for Complex Network Analysis and Visualization
GEPIA2	GEPIA 2
muTarget	| muTarget
AlphaFold	AlphaFold Server - Google DeepMind
RamPlot	Ramachandran Map
TLR3 (UniProtKB with accession ID O15455)	TLR3-Toll-like receptor 3-Homo sapiens (Human)| UniProtKB|UniProt
PDB ID- 5GS0	RCSB PDB- 5GS0: Crystal structure of the complex of TLR3 and bi-specific diabody