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. 2025 Aug 22;15:30837. doi: 10.1038/s41598-025-05599-5

Table 4.

Analysis of the high-risk nsSNPs in TLR3’s evolutionary conservation profile using the NetSurfP 2.0 database.

Mutations Class Assignment Secondary Structure RSA (%) ASA (A²)
N284I Buried Coil 3 4
C37R Buried Coil 2 3
Q538P Buried Coil 11 20
L360P Buried Strand 2 4

RSA: relative surface accessibility [¼ ASA/Max ASA].

ASA: absolute surface accessibility.