Table 2.
Association between the expression of LDH-C4 and the clinicopathological factors of cervical carcinoma patients
| Clinical pathological parameters | N | Serum LDH-C4 | P value | Exosomal LDH-C4 | P value | |||
|---|---|---|---|---|---|---|---|---|
| High | Low | High | Low | |||||
| n (%) | n (%) | n (%) | n (%) | |||||
| Age (year) | <50 | 42 | 34 (80.95) | 8 (19.05) | 0.403 | 27 (64.28) | 15 (35.72) | 0.336 |
| ≥50 | 78 | 61 (78.20) | 17 (11.80) | 52 (66.66) | 26 (33.34) | |||
| Tumor size (cm) | ≤4 | 84 | 68 (80.95) | 16 (19.05) | 0.691 | 66 (78.57) | 28 (21.43) | 0.578 |
| >4 | 36 | 27 (75.00) | 9 (25.00) | 23 (63.88) | 13 (36.12) | |||
| Histology Grade | G1-G2 | 77 | 58 (75.32) | 19 (24.68) | 0.037 | 44 (57.14) | 33 (42.86) | 0.022 |
| G3 | 43 | 37 (86.04) | 6 (13.96) | 35 (81.39) | 8 (18.61) | |||
| Tumor stage | I | 68 | 50 (73.52) | 18 (26.48) | 0.023 | 38 (55.88) | 30 (44.12) | 0.019 |
| II-Ⅳ | 52 | 45 (86.53) | 7 (13.47) | 41 (78.84) | 11 (21.16) | |||
| Lymph node metastasis | Without | 75 | 59 (78.66) | 16 (21.34) | 0.009 | 47 (62.66) | 28 (37.34) | 0.016 |
| With | 55 | 46 (83.63) | 9 (16.37) | 42 (76.36) | 13 (23.64) | |||
| Vascular invasion | Without | 57 | 46 (80.70) | 11 (19.30) | 0.438 | 39 (68.42) | 18 (31.58) | 0.315 |
| With | 63 | 49 (77.77) | 14 (22.23) | 40 (63.49) | 23 (36.51) | |||
| Infiltrating depth | <1/2 | 48 | 38 (79.16) | 10 (20.84) | 0.357 | 30 (62.50) | 18 (37.50) | 0.441 |
| ≥1/2 | 72 | 57(79.16) | 15(20.84) | 49 (68.05) | 23 (31.95) | |||
| HPV infection | Negative | 34 | 27 (79.41) | 7 (20.59) | 0.172 | 22 (64.71) | 12 (35.29) | 0.262 |
| Positive | 86 | 68 (79.06) | 18 (20.94) | 57 (66.27) | 29 (33.73) | |||
Data analysis was performed using the Chi square test. P≤0.05 was considered statistically significant.