Fig. 7.

Therapeutic strategies targeting biomolecular phase separation in cancer. a Small molecules could promote biomolecular phase separation, inducing the formation or remodeling of functional condensates, enableing precise control over signaling pathways, cell death, and metabolism. b Small molecules have been shown to dissolve pathological condensates by interfering with multivalent interactions that promote phase separation. This process leads to the disassembly of aberrant biomolecular compartments, impairing their oncogenic functions and sensitizing cancer cells to treatment