Table 6.
Number of interfacing residues and different interaction of AgrA-AgrC and AgrB-AgrD of S. aureus and S. Epidermidis. Binding affinity (ΔG0) and dissociation score (Kd) at 37 °C analyzed using PRODIGY server
| Protein | No. of interface residues | Interface distance (Å) | ΔG0 (kcal mol−1) | Kd at 37 ℃ | Salt bridge | Disulfide bond | Hydrogen bond | Nonbond |
|---|---|---|---|---|---|---|---|---|
| AgrA-AgrC (S. aureus) | ||||||||
| AgrA | 22 | 1106 | −9.1 | 4.1 × 10−7 | 2 | 0 | 1 | 192 |
| AgrC | 20 | 1156 | ||||||
| AgrA-AgrC (S. epidermidis) | ||||||||
| AgrA | 23 | 1261 | −9.2 | 3.2 × 10−7 | 0 | 0 | 5 | 180 |
| AgrC | 25 | 1202 | ||||||
| AgrB-AgrD (S. aureus) | ||||||||
| AgrB | 18 | 784 | −6.6 | 2.1 × 10−5 | 0 | 0 | 2 | 154 |
| AgrD | 14 | 937 | ||||||
| AgrB-AgrD (S. epidermidis) | ||||||||
| AgrB | 16 | 716 | −5.5 | 1.3 × 10−5 | 0 | 0 | 0 | 149 |
| AgrD | 10 | 802 | ||||||