Table 3.

Identification of prognostic factors in EBER-/EBV DNA- patients by univariate and multivariate Cox regression analysis^a

Characteristic	Univariate		Multivariate
	HR (95% CI)	P value	HR (95% CI)	P value
LRFFS
Age (years)	1.031 (0.959–1.109)	0.407
Gender
Male	1.000 (Reference)
Female	0.441 (0.084–2.306)	0.332
Histology
Keratinizing	1.000 (Reference)		1.000 (Reference)
Nonkeratinizing	5.170 (1.124–23.792)	0.035	2.480 (0.345–17.836)	0.367
T category	0.983 (0.441–2.192)	0.967
N category	1.375 (0.604–3.130)	0.448
III b	1.579 (1.113–2.240)	0.011	1.399 (0.917–2.134)	0.120
NI b	1.174 (0.669–2.061)	0.576
OS
Age (years)	1.017 (0.923–1.120)	0.740
Gender
Male	1.000 (Reference)
Female	0.333 (0.034–3.271)	0.346
Histology
Keratinizing	1.000 (Reference)		1.000 (Reference)
Nonkeratinizing	11.490 (1.104-119.619)	0.041	6.060 (0.359–102.200)	0.211
T category	0.861 (0.321–2.309)	0.766
N category	1.979 (0.657–5.965)	0.225
III	1.672 (1.057–2.645)	0.028	1.389 (0.832–2.318)	0.209
NI	1.288 (0.611–2.712)	0.506
aVariable exhibiting a P value less than 0.05 in the univariate Cox regression analysis were futher included in multivariate Cox regression analysis
bThe calculation of III and NI is detailed elsewhere [18]
EBER, EBV-encoded small ribonucleic acid; EBV, Epstein-Barr virus; III, immune inflammation index; LRFFS, locoregional failure-free survival; NI, nutrition index; OS, overall survival