Table 3.
Association of blood parameters and genetic variants analyzed in patients with schizophrenia
| Characteristics, mean (SD) | Genotypes | Statistics | ||
|---|---|---|---|---|
| IL10/rs1554286 | GG | GA | AA | |
| Lymphocytes | 2.2 (0.7) | 2.6 (2.1) | 2.3 (0.7) | F = 0.91, p = 0.4 |
| Monocytes | 0.5 (0.2) | 0.6 (0.7) | 0.5 (0.2) | F = 0.87, p = 0.41 |
| Neutrophils | 3.8 (1.4) | 3.7 (1.3) | 4.1 (1.7) | F = 1.57, p = 0.21 |
| Platelets | 247.5 (68.5) | 250.2 (60.8) | 235 (72.4) | F = 0.94, p = 0.39 |
| NLR | 1.8 (0.9) | 1.7 (1.4) | 1.9 (1.1) | F = 1.09, p = 0.33 |
| MLR | 0.2 (0.1) | 0.2 (0.3) | 0.2 (0.1) | F = 0.59, p = 0.55 |
| PLR | 120 (54.1) | 120.6 (106) | 108.7 (46.1) | F = 0.37, p = 0.68 |
| MPV | 8.9 (1.3) | 9 (1) | 9.3 (1.8) | F = 1.37, p = 0.25 |
| TNF/rs1800629 | GG | GA | AA | |
| Lymphocytes | 2.4 (1.6) | 2.8 (0.9) | - | t = −1.5, p = 0.14 |
| Monocytes | 0.5 (0.5) | 0.5 (0.1) | - | t = −0.06, p = 0.94 |
| Neutrophils | 3.8 (1.4) | 4.1 (1.7) | - | t = −0.65, p = 0.52 |
| Platelets | 244.9 (65.3) | 266.8 (67.7) | - | t = −1.16, p = 0.26 |
| NLR | 1.7 (1.2) | 1.7 (1.1) | - | t = 0.26, p = 0.79 |
| MLR | 0.2 (0.2) | 0.2 (0.1) | - | t = 1.41, p = 0.16 |
| PLR | 118.8 (85.3) | 104.6 (43.6) | - | t = 1.09, p = 0.28 |
| MPV | 9 (1.3) | 9.1 (0.7) | - | t = −0.29, p = 0.79 |
| TLR2/rs7656411 | TT | TG | GG | |
| Lymphocytes | 2.5 (1.9) | 2.2 (0.8) | 2.3 (0.7) | F = 0.58, p = 0.55 |
| Monocytes | 0.5 (0.2) | 0.6 (0.7) | 1.1 (1.6) | F = 5.57, p = 0.004 |
| Neutrophils | 3.8 (1.5) | 3.9 (1.3) | 3.9 (1.8) | F = 0.21, p = 0.8 |
| Platelets | 244.9 (63.5) | 250 (68.9) | 236.9 (78.8) | F = 0.23, p = 0.79 |
| NLR | 1.7 (1.3) | 1.91 (1.1) | 1.7 (0.7) | F = 0.78, p = 0.45 |
| MLR | 0.2 (0.1) | 0.2 (0.2) | 0.4 (0.6) | F = 5.49, p = 0.004 |
| PLR | 114.3 (92.7) | 125.9 (63.1) | 113 (62.9) | F = 0.5, p = 0.6 |
| MPV | 9.2 (1.4) | 8.8 (1.1) | 8.8 (0.9) | F = 2.18, p = 0.11 |
| TLR6/rs5743827 | CC | CT | TT | |
| Lymphocytes | 2.3 (0.8) | 2.9 (3.3) | 2.5 (0.6) | F = 2.25, p = 0.1 |
| Monocytes | 0.5 (0.6) | 0.5 (0.2) | 0.5 (0.1) | F = 0.15, p = 0.85 |
| Neutrophils | 3.9 (1.4) | 3.6 (1.4) | 4.3 (1.6) | F = 0.73, p = 0.48 |
| Platelets | 244.7 (66.8) | 251.8 (62.9) | 249.7 (54.7) | F = 0.22, p = 0.8 |
| NLR | 1.8 (1.3) | 1.5 (0.9) | 1.8 (0.7) | F = 1.53, p = 0.21 |
| MLR | 0.2 (0.2) | 0.2 (0.1) | 0.2 (0.05) | F = 0.65, p = 0.52 |
| PLR | 121.2 (90.5) | 107.1 (54) | 104.1 (34.1) | F = 0.61, p = 0.54 |
| MPV | 9 (1.1) | 9.1 (1.9) | 9.1 (0.7) | F = 0.23, p = 0.79 |
NLR Neutrophil/lymphocyte ratio, MLR Monocyte/lymphocyte ratio, PLR Platelet/lymphocyte ratio, MPV Mean platelet volume
Bolded text indicates a p-value below 0.0125 (4 SNPs/0.05)