Table 4.
Associations of AFB, ALB, numbers of pregnancies, and number of live births with the risk of osteoarthritis
| Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
| OR (95%CI) | P for trend | OR (95%CI) | P for trend | OR (95%CI) | P for trend | |
| AFB (years) | 0.044 | 0.056 | 0.693 | |||
| ≤ 23 | 1.00 | 1.00 | 1.00 | |||
| 24–26 | 0.85 (0.74, 0.97)* | 0.83 (0.72, 0.95)* | 0.90 (0.78, 1.04) | |||
| 27–29 | 0.89 (0.70, 1.13) | 0.91 (0.76, 1.08) | 0.96 (0.60, 1.24) | |||
| 30–32 | 0.92 (0.77, 1.09) | 0.90 (0.71, 1.15) | 1.06 (0.88, 1.26) | |||
| 33–35 | 0.95 (0.73, 1.17) | 0.96 (0.73, 1.18) | 1.11 (0.86, 1.42) | |||
| ≥ 36 | 0.97 (0.62, 1.52) | 0.98 (0.63, 1.54) | 1.20 (0.76, 1.88) | |||
| ALB (years) | 0.678 | 0.952 | 0.219 | |||
| ≤ 23 | 1.00 | 1.00 | 1.00 | |||
| 25–29 | 0.90 (0.78, 1.03) | 0.90 (0.78, 1.03) | 0.95 (0.82, 1.09) | |||
| 30–34 | 0.62 (0.49, 0.79)*** | 0.69 (0.54, 0.87)*** | 0.83 (0.72, 0.96) | |||
| 35–39 | 0.72 (0.61, 0.84)*** | 0.75 (0.65, 0.87)*** | 0.89 (0.76, 1.05) | |||
| ≥ 40 | 0.73 (0.63, 0.84)*** | 0.76 (0.65, 0.89)*** | 0.90 (0.69, 1.12) | |||
| Number of | 0.602 | 0.912 | 0.919 | |||
| Pregnancies, times | ||||||
| ≤ 2 | 1.00 | 1.00 | 1.00 | |||
| 3 | 0.92 (0.80, 1.06) | 0.93 (0.80, 1.07) | 0.89 (0.77, 1.03) | |||
| 4 | 0.99 (0.87, 1.13) | 1.03 (0.90, 1.17) | 1.00 (0.88, 1.15) | |||
| ≥ 5 | 1.02 (0.90, 1.17) | 1.04 (0.91, 1.18) | 1.02 (0.89, 1.17) | |||
| Number of | < 0.001 | 0.018 | 0.024 | |||
| Live births, times | ||||||
| ≤ 2 | 1.00 | 1.00 | 1.00 | |||
| 3 | 0.95 (0.85, 1.07) | 0.97 (0.86, 1.09) | 0.96 (0.86, 1.09) | |||
| 4 | 0.87 (0.76, 1.01) | 0.90 (0.78, 1.05) | 0.90 (0.78, 1.04) | |||
| ≥ 5 | 0.76 (0.66, 0.88)*** | 0.84 (0.72, 0.98)* | 0.85 (0.72, 0.99)* | |||
Abbreviations: AFB age at first birth, ALB age at last birth, OR odds ratio, CI confidence interval
Model 1: age and race/ethnicity
Model 2: model 1 variables plus education level, marital status, family poverty-income ratio, hypertension, diabetes mellitus, smoker, alcohol user
Model 3 was adjusted for model 2 variables plus body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, mean energy intake, hemoglobin, fast glucose, alkaline phosphatase, total protein, sodium, phosphorus, calcium, potassium, menopause status, oral contraceptive use, use female hormones, had a hysterectomy, both ovaries removed, blood urea nitrogen, uric acid, serum creatinine, estimated glomerular filtration rate, total cholesterol, triglyceride, high-density lipoprotein-cholesterol, age at menarche, age at menopause, and fertile lifespan
*P < 0.05, **P < 0.01, ***P < 0.001