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YAP-mediated Nrf2 translocation to the nucleus ameliorates ferroptosis in II/R-Induced ALI. Overexpression of YAP (OE-YAP) promotes the translocation of Nrf2 into the nucleus, where it activates the HO-1 promoter, leading to increased HO-1 expression. HO-1 mitigates ferroptosis by reducing ROS and inhibiting lipid peroxidation, thereby alleviating ALI.
