Table 1.
General characteristics of the enrolled women
| Variable | Controls | GH | PE | sPE | P-value |
|---|---|---|---|---|---|
| (n = 41) | (n = 45) | (n = 47) | (n = 73) | ||
| Age, years | 28.20 ± 4.79 | 29.24 ± 5.52 | 29.81 ± 5.83 | 30.52 ± 6.19 | 0.21 |
| BMI (kg/m2) | 28.17 ± 3.84 | 30.40 ± 3.30 | 30.70 ± 4.51 | 31.59 ± 4.72 | < 0.001 |
| GA | 38.86 ± 0.90 | 38.39 ± 1.78 | 37.56 ± 2.25 | 35.64 ± 3.66 | < 0.001 |
| SBP (mmHg) | 117.83 ± 19.64 | 141.13 ± 9.97 | 148.68 ± 9.60 | 165.55 ± 17.14 | < 0.001 |
| DBP (mmHg) | 81.10 ± 6.60 | 95.20 ± 6.69 | 99.00 ± 4.78 | 109.04 ± 15.42 | < 0.001 |
| ALP (IU/L) | 124.49 ± 36.70 | 139.94 ± 53.53 | 147.43 ± 47.68 | 136.00 ± 45.57 | 0.138 |
| LDH(IU/L) | 178.43 ± 37.75 | 208.77 ± 53.66 | 228.54 ± 59.67 | 255.26 ± 66.36 | < 0.001 |
| ALT (IU/L) | 9.46 ± 4.63 | 9.76 ± 5.93 | 9.69 ± 5.61 | 13.12 ± 8.00 | 0.004 |
| AST (IU/L) | 14.93 ± 4.48 | 15.62 ± 6.10 | 17.06 ± 7.23 | 20.06 ± 7.68 | < 0.001 |
| BUN (mmol/L) | 3.48 ± 1.23 | 3.37 ± 0.90 | 3.84 ± 1.30 | 4.17 ± 2.00 | 0.02 |
| SCr (umol/L) | 49.42 ± 9.55 | 55.24 ± 12.20 | 60.51 ± 14.78 | 62.87 ± 25.80 | 0.002 |
| UA (umol/L) | 284.65 ± 60.78 | 325.37 ± 79.26 | 383.55 ± 108.92 | 397.04 ± 95.69 | < 0.001 |
| WBC (109/L) | 9.13 ± 2.17 | 9.28 ± 1.92 | 8.59 ± 1.98 | 9.43 ± 2.20 | 0.187 |
| PDW(fL) | 12.93 ± 2.19 | 14.16 ± 2.02 | 15.05 ± 2.01 | 15.60 ± 2.01 | < 0.001 |
| MPV (fL) | 10.81 ± 1.08 | 11.14 ± 1.27 | 11.49 ± 1.28 | 11.25 ± 1.21 | 0.077 |
| PLT (109/L) | 219.73 ± 50.67 | 219.33 ± 67.04 | 199.38 ± 61.77 | 197.30 ± 68.13 | 0.128 |
| NT-proBNP (pg/mL) | 20.50(12.05,28.00) | 42.50(30.00,61.40) | 144.60(77.80,209.50) | 266.8(160.60,379.65) | < 0.001 |
| Adverse pregnancy outcomes | 0 | 8 (17.8%) | 22 (44.7%) | 55 (75.3%) | < 0.001 |
GA Gestational age, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, ALP alkaline phosphatase, LDH lactate dehydrogenase, ALT alanine aminotransferase, AST aspartate aminotransferase, BUN blood urea nitrogen Alanine, SCr serum creatinine, UA uric acid, WBC white blood cell, PLT platelet, MPV mean platelet volume, PDW platelet distribution width, NT-proBNP N-terminal pro-brain natriuretic peptide. The data were analyzed by one-way ANOVA and Kruskal–Wallis tests