Skip to main content
. 2025 Aug 23;25:1367. doi: 10.1186/s12903-025-06687-8

Table 7.

Administration protocol of bisphosphonates in patients with OI

Antiresorptive Route of administration Doses
Pamidronat Intravenous

· <2 years: 0.37-0.75 mg/kg for 2-3 days every 2 months

· 2-3 years: 0.56-1.125 mg/kg for 2-3 days every 3 months

· >3 years: 0.75-1.5 mg/kg for 2-3 days every 4 months

· 1 st infusion at half dose
Zoledronic acid Intravenous

· <2 years: 0.025 mg/kg every 3 months

· >2 years: 0.05 mg/kg every 6 months

· 1 st infusion at half dose
Alendronate Oral

· <40 kg: 5 mg/day or 35 mg/week

· >40 kg: 10 mg/day or 70 mg/week
Risedronate Oral · 2,5-5 mg/day or 15-35 mg/week