Table 3.
Diagnostic performance of each model
| Set | Model | AUC (95% CI) | ACC (95% CI) | SEN (95% CI) | SPE (95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|---|---|---|
| Training | Clinical | 0.832 (0.755–0.908) | 0.682 (0.680–0.685) | 0.926 (0.827–1.0) | 0.637 (0.559–0.715) | 0.321 (0.217–0.424) | 0.979 (0.950–1.0) |
| Habiat1 | 0.930 (0.871–0.990) | 0.867 (0.866–0.868) | 0.889 (0.770–1.0) | 0.863 (0.807–0.919) | 0.545 (0.398–0.693) | 0.977 (0.951–1.0) | |
| Habiat2 | 0.935 (0.886–0.984) | 0.913 (0.912–0.914) | 0.852 (0.718–0.986) | 0.925 (0.882–0.967) | 0.676 (0.519–0.834) | 0.971 (0.943–0.999) | |
| Habiat3 | 0.910 (0.844–0.976) | 0.838 (0.837–0.840) | 0.852 (0.718–0.986) | 0.836 (0.775–0.896) | 0.489 (0.346–0.632) | 0.968 (0.938–0.999) | |
| Habiat WT | 0.919 (0.868–0.970) | 0.792 (0.790–0.794) | 0.926 (0.827–1.0) | 0.767 (0.699–0.836) | 0.424 (0.298–0.550) | 0.982 (0.958–1.0) | |
| Combined | 0.999 (0.996–1.0) | 0.983 (0.982–0.983) | 1.000 (1.0–1.0) | 0.979 (0.956–1.0) | 0.900 (0.793–1.0) | 1.000 (1.0–1.0) | |
| In-vad | Clinical | 0.818 (0.703–0.934) | 0.811 (0.807–0.815) | 0.722 (0.515–0.929) | 0.839 (0.743–0.935) | 0.591 (0.385–0.796) | 0.904 (0.824–0.984) |
| Habiat1 | 0.949 (0.902–0.997) | 0.919 (0.917–0.921) | 0.889 (0.744–1.0) | 0.929 (0.861–0.996) | 0.800 (0.625–0.975) | 0.963 (0.913–1.0) | |
| Habiat2 | 0.957 (0.900–1.0) | 0.959 (0.958–0.960) | 0.889 (0.744–1.0) | 0.982 (0.947–1.0) | 0.941 (0.829–1.0) | 0.965 (0.917–1.0) | |
| Habiat3 | 0.861 (0.760–0.963) | 0.838 (0.834–0.841) | 0.722 (0.515–0.929) | 0.875 (0.788–0.962) | 0.650 (0.441–0.859) | 0.907 (0.830–0.985) | |
| Habiat WT | 0.902 (0.828–0.976) | 0.851 (0.848–0.855) | 0.833 (0.661–1.0) | 0.857 (0.765–0.949) | 0.652 (0.458–0.847) | 0.941 (0.877–1.0) | |
| Combined | 1.000 (1.0–1.0) | 1.000 (1.0–1.0) | 1.000 (1.0–1.0) | 1.000 (1.0–1.0) | 1.000 (1.0–1.0) | 1.000 (1.0–1.0) | |
| Ex-vad | Clinical | 0.789 (0.704–0.873) | 0.660 (0.657–0.663) | 0.875 (0.760–0.990) | 0.602 (0.513–0.690) | 0.373 (0.264–0.483) | 0.947 (0.896–0.998) |
| Habiat1 | 0.862 (0.792–0.933) | 0.773 (0.771–0.776) | 0.812 (0.677–0.948) | 0.763 (0.686–0.839) | 0.481 (0.348–0.615) | 0.938 (0.889–0.986) | |
| Habiat2 | 0.802 (0.697–0.908) | 0.873 (0.872–0.875) | 0.750 (0.600–0.900) | 0.907 (0.854–0.959) | 0.686 (0.532–0.840) | 0.930 (0.884–0.977) | |
| Habiat3 | 0.859 (0.778–0.940) | 0.853 (0.852–0.855) | 0.812 (0.677–0.948) | 0.864 (0.803–0.926) | 0.619 (0.472–0.766) | 0.944 (0.901–0.988) | |
| Habiat WT | 0.828 (0.735–0.921) | 0.813 (0.811–0.815) | 0.812 (0.677–0.948) | 0.814 (0.743–0.884) | 0.542 (0.401–0.683) | 0.941 (0.896–0.987) | |
| Combined | 0.955 (0.922–0.988) | 0.833 (0.832–0.835) | 0.969 (0.908–1.0) | 0.797 (0.724–0.869) | 0.564 (0.433–0.695) | 0.989 (0.969–1.0) |
Habiat WT Habiat Whole_Tumor, AUC Area under the curve, ACC accuracy, SEN sensitivity, SPE specificity, NPV Negative predictive value, PPV Positive predictive value