Table 3.

Summary of diagnostic performance in differentiating pediatric nephrotic syndrome subtypes

Study	Biomarker	Comparison	Cutoff Value	AUC (95% CI)	Sensitivity (%)	Specificity (%)
Bennett et al.	Urinary NGAL/Cr	SRNS vs. SSNS	15 ng/mg	0.91	88.0%	88.0%
Bienias et al.	Urinary NGAL	SRNS vs. SSNS	13.1 ng/mL	0.90	86%	89%
Chehade et al.	Urinary NGAL/Cr	FSGS vs. MCD	17 ng/mg	0.76 (0.57–0.95)	77.0%	78.0%
Choudhary et al.	Urinary NGAL	SRNS vs. SSNS	13.1 ng/mL	0.90 (0.82–0.98)	85.7%	89.3%
El-Gamasy et al.	Urinary NGAL	SRNS vs. SSNS	315 ng/mL	0.90	86.7%	93.3%
Jwda et al.	Urinary NGAL	SRNS vs. SSNS	137 ng/mL	NA	95%	95%
Kumar et al.	Urinary NGAL	SDNS vs. (SRNS + (SSNS)	40.02 ng/mL	0.95 (0.90-1.00)	80.0%	93.3%
Nickavar et al.	Urinary NGAL/Cr	SRNS vs. SSNS	0.46 ng/mg	0.76 (0.62–0.90)	63.0%	92.0%

FSGS: focal segmental glomerulosclerosis, MCD: minimal change disease, SDNS: steroid-dependent nephrotic syndrome