Table 3.
Univariate and Multivariate Analysis of Prognostic Factors for OS in Patients with Diffuse Large B-cell Lymphoma.
| Variable | Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|---|
| PH Assumption | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age | |||||
| <60 | 0.075 | 1 | |||
| ≥60 | 1.3037 (0.4684-3.629) | 0.612 | |||
| ECOG score | |||||
| < 2 | 0.5 | 1 | |||
| ≥ 2 | 3.4269 (1.079-10.89) | 0.0368* | |||
| Sites | |||||
| <2 | 0.73 | 1 | |||
| ≥2 | 1.003464 (0.2251-4.473) | 0.996 | |||
| LDH | |||||
| Normal | 0.59 | 1 | |||
| Elevated | 0.8511 (0.2722-2.661) | 0.782 | |||
| Stage | |||||
| I & II | 0.75 | 1 | |||
| III & IV | 1.6261 (0.5977-4.424) | 0.341 | |||
| RDW (%) | |||||
| ≤ 14.355 | 0.063 | 1 | |||
| > 14.355 | 1.2622 (0.4647-3.428) | 0.648 | |||
| PLT (x 103 / μL) | |||||
| < 315.5 | 0.32 | 1 | 1 | ||
| ≥ 315.5 | 0.7668 (0.2825-2.082) | 0.602 | 0.3117 (0.1039-0.9347) | 0.03749* | |
| ANC (x 103 / μL) | |||||
| < 5.29 | 0.46 | 1 | |||
| ≥ 5.29 | 2.2098 (0.7958-6.136) | 0.128 | |||
| ALC (x 103 / μL) | |||||
| < 1.59 | 0.45 | 1 | |||
| ≥ 1.59 | 0.3963 (0.1428-1.099) | 0.0754 | |||
| AMC (x 103 / μL) | |||||
| ≤ 0.625 | 0.95 | 1 | 0.116 | 1 | |
| > 0.625 | 2.2646 (0.8172-6.276) | 5.9301 (1.7298-20.3296) | 0.00463** | ||
| IPI | |||||
| Low Risk | 0.2 | 0.4969 (0.05843-4.227) | 0.522 | ||
| Low-Intermediate Risk | 1.1142 (0.13070-9.498) | 0.921 | |||
| High-Intermediate Risk | 0.6765 (0.06880-6.652) | 0.738 | |||
| High Risk | 1 | ||||
| SII | |||||
| < 1,210.615 | 0.24 | 1 | 1 | ||
| ≥ 1,210.615 | 4.0996 (1.409-11.93) | 0.00964** | 3.5493 (1.0106-12.4651) | 0.04810* | |
| PLR | |||||
| < 193.415 | 0.43 | 1 | 1 | ||
| ≥ 193.415 | 4.3724 (1.498-12.77) | 0.00696** | 5.2951 (1.4215-19.7252) | 0.01299* | |
| NLR | |||||
| < 3.425 | 0.39 | 1 | |||
| ≥ 3.425 | 2.6020 (0.9385-7.214) | 0.0661 | |||
| LMR | |||||
| < 2.71 | 0.95 | 1 | |||
| ≥ 2.71 | 0.2397 (0.08248-0.6963) | 0.00866** | |||