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. 2025;26(6):2129–2136. doi: 10.31557/APJCP.2025.26.6.2129

Table 3.

Binding Affinities (Kcal/mol) from 1-Click Docking between Conventional Ligands and Oil Blend Compounds Targeting p16INK4a

Ligand Target Molecule Molecular
Affinity (Kcal/mol)
Cisplatin P16 INK4a -5.5
Paclitaxel P16 INK4a -5.4
Bevacizumab P16 INK4a -4.8
Pembrolizumab P16 INK4a -4.7
Topotecan P16 INK4a -5.1
Curcumin P16 INK4a -7.8
Resveratrol P16 INK4a -8.2
Epigallocatechin gallate P16 INK4a -8
Olaparib P16 INK4a -5.8
Everolimus P16 INK4a -6.7
Temsirolimus P16 INK4a -5.9
Oleic Acid P16 INK4a -3.7
g-Tocopherol P16 INK4a -7.9
Sitosterol P16 INK4a -7.9
quercetin 3-O-glucoside P16 INK4a -8.7
apigenin 5-O-glucoside P16 INK4a -8.9
kaempferol 3-O-glycoside P16 INK4a -7.6
Eugenol P16 INK4a -8
Eugenyl Acetate P16 INK4a -8.8
b-Caryophillene P16 INK4a -7.3