Table 3.
Distribution of XRCC1 (rs25487) Genotype and Allele Frequencies among the Studied Groups
| Group I (HCC) (n=30) | Group II (Hepatitis C) (n=30) |
Group III(Control) (n=30) |
χ2 | P - Value | Significance b/w groups |
||||
|---|---|---|---|---|---|---|---|---|---|
| No. | % | No. | % | No. | % | ||||
| Genotypes | |||||||||
| GG | 7 | 23.3 | 14 | 46.7 | 22 | 73.4 | 19.4 | 0.001 | P1=0.033* |
| AA | 14 | 46.7 | 5 | 16.6 | 3 | 10 | P2<0.001* | ||
| GA | 9 | 30 | 11 | 36.7 | 5 | 16.6 | P3=0.123 | ||
| GG | 7 | 23.3 | 14 | 46.7 | 22 | 73.4 | 15.05 | 0.001 | P1=0.103 |
| P2<0.001* | |||||||||
| AA + GA | 23 | 76.7 | 16 | 53.3 | 8 | 26.6 | P3=0.064 | ||
| Alleles | P1=0.117 | ||||||||
| G | 17 | 42.5 | 25 | 62.5 | 27 | 79.4 | 10.58 | 0.005 | P2<0.002* |
| A | 23 | 57.5 | 15 | 37.5 | 7 | 20.6 | P3=0.133 | ||
χ2, p, χ2 and p values for Chi square test for comparing between the three groups; Significance among groups was done using Fisher Exact test; *, Statistically significant at p ≤ 0.05; p1, p value for comparing between group I and group II; p2, p value for comparing between group I and group III; p3, p value for comparing between group II and group III