Table 3.
Association of VEGF +405C/G Polymorphism with Gastrointestinal Cancer Risk According to Ethnicity
| Model | Ethnicity | Number of studies | Test of association | Test of heterogeneity | Publication bias | ||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | p-value | Model | p-value | I2 | Egger's test | |||
| p-value | |||||||||
| Allele contrast | Overall | 23 | 1.02 | (0.92- 1.13) | 0.67 | Random | 0 | 0.7 | 0.62 |
| (G vs. C) | |||||||||
| Asian | 12 | 1.11 | (0.98- 1.26) | 0.09 | Random | 0.0007 | 0.66 | 0.17 | |
| Caucasian | 8 | 0.92 | (0.74- 1.14) | 0.44 | Random | 0 | 0.78 | 0.09 | |
| Middle East | 2 | 0.92 | (0.56- 1.51) | 0.74 | Random | 0.02 | 0.81 | NA | |
| Mixed | 1 | 0.81 | (0.61- 1.08) | 0.15 | Fixed | NA | NA | NA | |
| Recessive model (GG vs. GC+CC) | Overall | 23 | 1.08 | (0.95- 1.23) | 0.22 | Random | 0 | 0.62 | 0.87 |
| Asian | 12 | 1.18 | (0.98- 1.42) | 0.08 | Random | 0.0006 | 0.66 | 0.12 | |
| Caucasian | 8 | 1.01 | (0.81- 1.27) | 0.89 | Random | 0.017 | 0.59 | 0.29 | |
| Middle East | 2 | 0.96 | (0.49- 1.90) | 0.92 | Random | 0.021 | 0.81 | NA | |
| Mixed | 1 | 0.79 | (0.54- 1.18) | 0.26 | Fixed | NA | NA | NA | |
| Dominant model (GG+GC vs. CC) | Overall | 23 | 0.96 | (0.78- 1.16) | 0.65 | Random | 0 | 0.67 | 0.58 |
| Asian | 12 | 1.11 | (0.85- 1.46) | 0.43 | Random | 0.0001 | 0.7 | 0.48 | |
| Caucasian | 8 | 0.8 | (0.54- 1.19) | 0.28 | Random | 0.0009 | 0.71 | 0.12 | |
| Middle East | 2 | 0.84 | (0.57- 1.25) | 0.4 | Fixed | 0.248 | 0.25 | NA | |
| Mixed | 1 | 0.69 | (0.39- 1.22) | 0.21 | Fixed | NA | NA | NA | |
| Overdominant (GC vs. CC +GG) | Overall | 23 | 0.89 | (0.79- 1.02) | 0.09 | Random | 0 | 0.63 | 0.17 |
| Asian | 12 | 0.89 | (0.74- 1.08) | 0.25 | Random | 0.0001 | 0.72 | 0.24 | |
| Caucasian | 8 | 0.87 | (0.70- 1.09) | 0.23 | Random | 0.016 | 0.59 | 0.46 | |
| Middle East | 2 | 0.85 | (0.65- 1.12) | 0.26 | Fixed | 0.132 | 0.56 | NA | |
| Mixed | 1 | 1.05 | (0.72- 1.55) | 0.78 | Fixed | NA | NA | NA | |
| GG vs. CC | Overall | 23 | 1.01 | (0.83- 1.25) | 0.86 | Random | 0 | 0.65 | 0.75 |
| Asian | 12 | 1.2 | (0.89- 1.60) | 0.21 | Random | 0.0003 | 0.68 | 0.28 | |
| Caucasian | 8 | 0.87 | (0.59- 1.29) | 0.5 | Random | 0.0032 | 0.67 | 0.1 | |
| Middle East | 2 | 0.8 | (0.36- 1.81) | 0.59 | Random | 0.075 | 0.68 | NA | |
| Mixed | 1 | 0.64 | (0.35- 1.17) | 0.15 | Fixed | NA | NA | NA | |
| GG vs. GC | Overall | 23 | 1.11 | (0.98- 1.27) | 0.1 | Random | 0.0004 | 0.57 | 0.46 |
| Asian | 12 | 1.18 | (0.97- 1.44) | 0.1 | Random | 0.0004 | 0.68 | 0.15 | |
| Caucasian | 8 | 1.09 | (0.95- 1.25) | 0.23 | Fixed | 0.11 | 0.4 | 0.75 | |
| GG vs. GC | Middle East | 2 | 1.03 | (0.55- 1.95) | 0.92 | Random | 0.042 | 0.76 | NA |
| Mixed | 1 | 0.85 | (0.56- 1.28) | 0.44 | Fixed | NA | NA | NA | |
| GC vs. CC | Overall | 23 | 0.91 | (0.75- 1.12) | 0.37 | Random | 0 | 0.65 | 0.41 |
| Asian | 12 | 1.04 | (0.77- 1.39) | 0.79 | Random | 0.0001 | 0.72 | 0.86 | |
| Caucasian | 8 | 0.79 | (0.54- 1.15) | 0.21 | Random | 0.006 | 0.65 | 0.19 | |
| Middle East | 2 | 0.79 | (0.52- 1.20) | 0.27 | Fixed | 0.699 | 0 | NA | |
| Mixed | 1 | 0.75 | (0.41- 1.36) | 0.35 | Fixed | NA | NA | NA | |