Table 4.
Association of VEGF +405C/G Polymorphism with Gastrointestinal Cancer Risk According to Cancer Type
| Model | Cancer type | Number of studies | Test of association | Test of heterogeneity | Publication bias | ||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | p-value | Model | p-value | I2 | Egger's test | |||
| p-value | |||||||||
| Allele contrast | Overall | 23 | 1.02 | (0.92- 1.13) | 0.67 | Random | 0 | 0.7 | 0.62 |
| (G vs. C) | |||||||||
| Colorectal | 7 | 1.09 | (0.99- 1.19) | 0.07 | Fixed | 0.107 | 0.42 | 0.39 | |
| Esophageal | 3 | 1.29 | (1.11- 1.51) | 0.001 | Fixed | 0.326 | 0.11 | 0.47 | |
| Gastric | 8 | 0.94 | (0.78- 1.12) | 0.49 | Random | 0.0002 | 0.75 | 0.22 | |
| Hepatocellular | 2 | 0.88 | (0.75- 1.04) | 0.14 | Fixed | 0.813 | 0 | NA | |
| Oral | 1 | 0.93 | (0.63- 1.36) | 0.7 | Fixed | NA | NA | NA | |
| Pancreatic | 2 | 0.73 | (0.19- 2.86) | 0.65 | Random | 0.0001 | 0.94 | NA | |
| Recessive model (GG vs. GC+CC) | Overall | 23 | 1.08 | (0.95- 1.23) | 0.22 | Random | 0 | 0.62 | 0.87 |
| Colorectal | 7 | 1.22 | (0.99- 1.51) | 0.059 | Random | 0.032 | 0.56 | 0.7 | |
| Esophageal | 3 | 1.41 | (1.15- 1.72) | 0.0008 | Fixed | 0.46 | 0 | 0.5 | |
| Gastric | 8 | 0.92 | (0.76- 1.11) | 0.39 | Random | 0.032 | 0.54 | 0.49 | |
| Hepatocellular | 2 | 0.88 | (0.69- 1.12) | 0.29 | Fixed | 0.384 | 0 | NA | |
| Oral | 1 | 0.77 | (0.46- 1.29) | 0.32 | Fixed | NA | NA | NA | |
| Pancreatic | 2 | 1.17 | (0.31- 4.38) | 0.82 | Random | 0.014 | 0.83 | NA | |
| Dominant model (GG+GC vs. CC) | Overall | 23 | 0.96 | (0.78- 1.16) | 0.65 | Random | 0 | 0.67 | 0.58 |
| Colorectal | 7 | 0.96 | (0.81- 1.15) | 0.7 | Fixed | 0.36 | 0.08 | 0.06 | |
| Esophageal | 3 | 1.34 | (0.94- 1.89) | 0.09 | Fixed | 0.48 | 0 | 0.47 | |
| Gastric | 8 | 0.94 | (0.63- 1.39) | 0.75 | Random | 0 | 0.79 | 0.3 | |
| Hepatocellular | 2 | 0.79 | (0.58- 1.09) | 0.15 | Fixed | 0.49 | 0 | NA | |
| Oral | 1 | 1.36 | (0.60- 3.07) | 0.46 | Fixed | NA | NA | NA | |
| Pancreatic | 2 | 0.35 | (0.07- 1.77) | 0.2 | Random | 0.012 | 0.84 | NA | |
| Overdominant (GC vs. GG +CC) | Overall | 23 | 0.89 | (0.79- 1.02) | 0.09 | Random | 0 | 0.63 | 0.17 |
| Colorectal | 7 | 0.84 | (0.69- 1.02) | 0.075 | Random | 0.048 | 0.52 | 0.38 | |
| Esophageal | 3 | 0.78 | (0.64- 0.96) | 0.017 | Fixed | 0.851 | 0 | 0.54 | |
| Gastric | 8 | 1.1 | (0.98- 1.24) | 0.106 | Fixed | 0.19 | 0.3 | 0.29 | |
| Hepatocellular | 2 | 0.99 | (0.79- 1.25) | 0.971 | Fixed | 0.18 | 0.45 | NA | |
| Oral | 1 | 1.46 | (0.88- 2.45) | 0.144 | Fixed | NA | NA | NA | |
| Pancreatic | 2 | 0.35 | (0.22- 0.57) | 1.67 | Fixed | 0.407 | 0 | NA | |
| GG vs. CC | Overall | 23 | 1.02 | (0.83- 1.25) | 0.86 | Random | 0 | 0.65 | 0.75 |
| Colorectal | 7 | 1.13 | (0.93- 1.38) | 0.22 | Fixed | 0.25 | 0.24 | 0.4 | |
| Esophageal | 3 | 1.56 | (1.09- 2.24) | 0.016 | Fixed | 0.38 | 0 | 0.49 | |
| Gastric | 8 | 0.89 | (0.58- 1.36) | 0.58 | Random | 0 | 0.79 | 0.39 | |
| Hepatocellular | 2 | 0.76 | (0.54- 1.07) | 0.12 | Fixed | 0.89 | 0 | NA | |
| Oral | 1 | 1.14 | (0.49- 2.69) | 0.76 | Fixed | NA | NA | NA | |
| Pancreatic | 2 | 0.49 | (0.07- 3.36) | 0.47 | Random | 0.01 | 0.85 | NA | |
| GG vs. GC | Overall | 23 | 1.11 | (0.98- 1.27) | 0.1 | Random | 0.0004 | 0.57 | 0.46 |
| Colorectal | 7 | 1.26 | (1.00- 1.58) | 0.047 | Random | 0.027 | 0.58 | 0.97 | |
| Esophageal | 3 | 1.37 | (1.11- 1.69) | 0.0029 | Fixed | 0.65 | 0 | 0.52 | |
| Gastric | 8 | 0.92 | (0.81- 1.05) | 0.23 | Fixed | 0.19 | 0.29 | 0.94 | |
| Hepatocellular | 2 | 0.92 | (0.72- 1.19) | 0.53 | Fixed | 0.24 | 0.26 | NA | |
| Oral | 1 | 0.7 | (0.41- 1.20) | 0.19 | Fixed | NA | NA | NA | |
| Pancreatic | 2 | 2.03 | (1.18- 3.50) | 0.01 | Fixed | 0.26 | 0.22 | NA | |
| GC vs. CC | Overall | 23 | 0.91 | (0.75- 1.12) | 0.37 | Random | 0 | 0.65 | 0.41 |
| Colorectal | 7 | 0.85 | (0.70- 1.03) | 0.1 | Fixed | 0.36 | 0.08 | 0.005 | |
| Esophageal | 3 | 1.13 | (0.79- 1.64) | 0.49 | Fixed | 0.68 | 0 | 0.42 | |
| Gastric | 8 | 0.98 | (0.67- 1.44) | 0.93 | Random | 0.0001 | 0.76 | 0.22 | |
| Hepatocellular | 2 | 0.82 | (0.59- 1.15) | 0.25 | Fixed | 0.304 | 0.05 | NA | |
| Oral | 1 | 1.63 | (0.69- 3.85) | 0.26 | Fixed | NA | NA | NA | |
| Pancreatic | 2 | 0.26 | (0.07- 0.94) | 0.039 | Random | 0.06 | 0.71 | NA | |
Significant p-values are highlighted in bold