Table 1.

Various lncRNA and Their Role in Cancer Immunotherapy

lncRNA	Cancer type	In vitro/ in vivo	Model	Function	references
ANRIL	Burkitt lymphoma	in vitro	Burkitt lymphoma cells	ANRIL silencing inhibited proliferation; promoted the apoptosis ↓cyclin D1, ↓E2F transcription factor 1 ↓Bcl2	[104]
MIR22HG	colorectal cancer	in vitro	LoVo and HCT116	acts as tumor suppressor, silencing ofMIR22HG enhances tumor cell proliferation and survival overexpression of MIR22HG triggers T cell infiltration, enhancing Immunotherapy	[105]
AK036396	Lung , Colon cancer	in vitro	LLC, CT-26 cell	AK036396 knockdown downregulate PMN-MDSC immunosuppression Administration of siAK036396 delays tumor progression, stability of Fcnb	[106]
F630028O10Rik	Lung cancer	in vitro	LLC, MS1	↓VEGFA, ↓VEGFR2 inhibitendothelialcells clone formation, migration, invasion Injection of cholesterol‐modified siRNA‐F63into mice tumour tissues	[107]
		in vivo	C57BL/6 mice	inhibit tumour growth and progression by modulating tumour angiogenesis
LINC00449	Leukemia	in vitro	AML cells	overexpression of LINC00449 inhibit the cell proliferation and invasion	[108]
lncMX1-215	HNSCC Ovarian cancer	in vitro	HN4, HN6 and HN30 Cal27, SCC4, SCC25 Detroit 562 ,293 T, SCC7	inhibits tumor proliferation capacity suppress cancer metastasis	[109]
		in vivo	BALB/c nude mice
HOTTIP		in vitro	Neutrophils	enhance IL-6 expression,↑PD-L1	[110]
LINC-PIN	lung ,colon cancer	in vitro	HCT116, A549, &DLD1	Inhibits migration as well as invasion of cancer cells both in vitro/ in vivo	[111]
		in vivo	Mice