Figure 1.
(A) Chemical structures of selected ¹⁸F-labeled 2-nitroimidazoles used in PET imaging of tumor hypoxia. Adapted with permission from 34, an open access article under a CC-BY 4.0 license, copyright 2022 Springer Nature. (B) Hypoxic subvolumes and recurrence patterns within the primary GTV (two left rows) and dose coverage (two right rows) from the radiotherapy plan. White contours and “+” symbols mark the center of recurrent tumors. Red: GTV; yellow: hypoxic subvolumes; light blue: persistent hypoxia. (C-F) Five-year outcomes comparing more vs. less hypoxic tumors. Adapted with permission from 45, copyright 2020 Elsevier. GTV: gross tumor volume; TMR: tumor-to-muscle ratio; PET: positron emission tomography.