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(A) Flowchart of a randomized phase II trial using 18F-FMISO-based PET/CT. (B-E) FMISO PET images (B, D) and corresponding planning CT (C, E) illustrating a dynamic dose painting strategy based on hypoxic subvolumes. (F) Recurrence patterns across treatment arms A, B, and C. Adapted with permission from 90, copyright 2022 Elsevier. PET: positron emission tomography; CT: computed tomography.
