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. 2025 Jul 11;15(16):7925–7939. doi: 10.7150/thno.114467

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Cellular uptake of M1M@Ds, their effects on repolarize M2 macrophages, and ICD in B16F10 tumor cells. (A) The cellular uptake of M1M@Ds was assessed using confocal microscopy and (B) FCM analysis. (C) FCM of the effects of M1NVs, hMnO_xs, M1NV@hMnO_xs, and M1M@Ds on polarization of M2 macrophages (D) Changes in cellular CD86 expression. (E) Changes in cellular CD206 expression. (F) ATP secretion of B16F10 tumor cells treated with M1M@Ds. (H) CRT exposure was evaluated through confocal microscopy observations and (G) flow cytometry analysis. (I) Confocal microscopy images demonstrated the relocation of HMGB1 from the nucleus to the cytoplasm in B16F10 tumor cells after M1M@Ds treatment. All data are expressed as mean ± SD (n = 3). The nuclei of the cells were labeled using DAPI, which is blue. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.