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. 2025 Jul 24;15(16):8202–8221. doi: 10.7150/thno.113382

Figure 3.

Figure 3

Mutation of ARHGEF12 is correlated with OM of GC. (A) Schematic of protein alterations in ARHGEF12. All alterations listed have been validated by Sanger sequencing. (B) Mutation frequency of ARHGEF12 in GC with OM. (C) Kaplan-Meier analysis of overall survival (OS) in GC patients with mutation (MUT) or wildtype (WT) ARHGEF12 from the TCGA-STAD cohort. (D) Representative images of immunohistochemistry (IHC) staining showed ARHGEF12 expression in six matched ATs, PTs and OMs. Scale bars, 100 µm. (E) Quantification of ARHGEF12 expression in (D). Data were presented as mean ± SEM. *P < 0.05, by paired two-tailed t-test or log-rank test.