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Evaluation of in vitro metabolic stability in human liver microsomes (HLM) and mouse liver microsomes (MLM) of selected N-(3-hydroxyphenyl)-3,8-diazabicyclooctanes.
| Compound | HLM t1/2 (min) | MLM t1/2 (min) |
|---|---|---|
| Morphine | > 145.0 | > 145.0 |
| Fentanyl | 53.4 | 4.6 |
| Atoxifent | 38.0 | 1.7 |
| 8 | 26.6 | 3.3 |
| 11 | 36.5 | 3.5 |
| 12 | 35.6 | 6.4 |
| 13 | 92.7 | 14.2 |
| 16 | 13.0 | 2.1 |
| 17 | 58.7 | 5.8 |
