Table 2. Associations between cardiac laboratory values with echocardiography and 99mTc-PYP scintigraphy parameters.
| Variable | Group | logBNP estimate (95% CI) | P value | logTroponin estimate (95% CI) | P value |
|---|---|---|---|---|---|
| LV mass | ATTRwt | 0.002 (−0.001 to 0.004) | 0.190 | 0.003 (−0.001 to 0.007) | 0.089 |
| ATTRm | 0.005 (0.002 to 0.009) | 0.005 | 0.009 (0.003 to 0.019) | 0.002 | |
| IVSd | ATTRwt | 0.51 (−0.18 to 1.19) | 0.140 | 1.33 (0.46 to 2.19) | 0.003 |
| ATTRm | 1.12 (0.25 to 1.98) | 0.013 | 2.17 (1.05 to 3.29) | <0.001 | |
| Positive PYP* | ATTRwt | 1.07 (−0.04 to 2.18) | 0.058 | 1.68 (0.49 to 2.87) | 0.007 |
| ATTRm | 1.99 (0.76 to 3.23) | 0.002 | 1.30 (−0.46 to 3.06) | 0.140 | |
| H/CL ratio | ATTRwt | 0.16 (−0.52 to 0.83) | 0.650 | 0.074 (−0.63 to 0.78) | 0.840 |
| ATTRm | 1.12 (0.02 to 2.22) | 0.047 | 1.32 (−0.061 to 2.71) | 0.060 |
*
Positive PYP includes results yielding Grade two or 3.
ATTRm, hereditary transthyretin amyloidosis; ATTRwt, wild type transthyretin amyloidosis; BNP, B-type natriuretic peptide; H/CL, heart-to-contralateral lung (ratio); IVSd, interventricular septal thickness at end-diastole; LV, left ventricular; 99mTc-PYP, technetium-99m pyrophosphate; PYP, pyrophosphate.