Skip to main content
. 2025 Jul 25;15(16):8488–8508. doi: 10.7150/thno.114534

Figure 7.

Figure 7

The mechanism of immune regulation. (A, B) The RT-qPCR results of the transcription of CXCR2 and PTEN in each group (n = 3). (C)IF images (400 ×) of the expression of PTEN in the tumor site of each group. (D) Representative images of MDSCs (CD11b+Gr-1+) in tumor of mice in different treatment groups. (E) Representative images of CD8+ T cells and CD4+ T cells in tumor of mice in different treatment groups. (F-G) Statistical analysis of CD11b+Gr-1+MDSCs and CD8+/CD4+ ratio (n = 3). (H) The frequency or percentage of different immune cells including MDSCs or NK cells (the proportion in total tumor cells), Tregs or CD8+ T cells (the proportion in CD45+CD3+ cell population), M2- or M1-macrophages (the proportion in the CD11b+F4/80+ cell population) as well as the summarized heat map of immune cells in tumors from each treatment. (n = 4, mean ± SD). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, one-way ANOVA.