Figure 2. Development trend analysis and future direction prediction for research on adverse events related to neoadjuvant immunotherapy in patients with perioperative cancer. (A) Regression curve analysis of global research hotspots on adverse events related to neoadjuvant immunotherapy. The coefficient of determination “R²” reflected the explanatory power of the model, and the regression coefficient “s” characterized the rate of temporal change. The effect of time on keyword frequency was considered statistically significant at p<0.05. (B) Hotspot burst analysis on adverse events related to neoadjuvant immunotherapy. PD-1, programmed cell death protein-1; PD-L1, programmed death-ligand 1.