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. 2025 Aug 21;15(8):e097863. doi: 10.1136/bmjopen-2024-097863

Table 6. Association rules of medications or their combinations and consecutive polypharmacy.

Antecedent (ATC-4) Support (%) Confidence (%) Lift
Glucocorticoids (H02AB) + HMG-CoA reductase inhibitors (C10AA) 5.02 20.60 2.71
Angiotensin-II receptor blockers (ARBs), plain (C09CA) + HMG-CoA reductase inhibitors 5.10 20.40 2.68
Angiotensin-II receptor blockers (ARBs), plain (C09CA) + Platelet aggregation inhibitors excl. heparin (B01AC) 5.07 20.20 2.65
HMG-CoA reductase inhibitors (C10AA) + Platelet aggregation inhibitors excl. heparin (B01AC) 5.61 17.88 2.35
H2-receptor antagonists (A02BA) 5.52 16.85 2.21
Third-generation cephalosporins (J01DD) 5.15 16.04 2.11
Angiotensin-II receptor blockers (ARBs), plain (C09CA) 5.80 15.99 2.10
Anilides (N02BE) 5.69 15.94 2.09
Platelet aggregation inhibitors excl. heparin (B01AC) 6.31 15.05 1.98
Vitamin D and analogues (A11CC) 5.37 15.00 1.97
HMG-CoA reductase inhibitors (C10AA) 6.36 14.89 1.95
Acetic acid derivatives and related substances (M01AB) 5.44 14.78 1.94
Glucocorticoids (H02AB) 6.06 12.12 1.59

ATC, Anatomical Therapeutic Chemical classification.