Table 3.

Univariate and Multivariate Cox Analyses to Evaluate the Predictors for Overall Survival

	Univariate Analysis		Multivariate Analysis		Bootstrap (n=1000)
	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
Gender	0.531 (0.313–0.901)	0.019*	0.627 (0.355–1.108)	0.108	0.618 (0.294–1.173)	0.185
Age	0.995 (0.969–1.020)	0.675
BMI	0.979 (0.869–1.104)	0.734
HAIC cycle	0.884 (0.732–1.067)	0.198
RALOX-HAIC	0.487 (0.274–0.865)	0.014*	0.607 (0.325–1.133)	0.117	0.630 (0.256–1.202)	0.193
CAE	0.357 (0.194–0.656)	0.001*	0.403 (0.213–0.762)	0.005*	0.390 (0.173–0.716)	0.011*
Systemic therapy	1.095 (0.706–1.699)	0.685
Viral hepatitis	1.333 (0.749–2.370)	0.328
Cirrhosis	0.888 (0.513–1.537)	0.671
ECOG score≥1	2.119 (1.252–3.585)	0.005*	1.168 (0.528–2.582)	0.703	1.303 (0.504–2.856)	0.719
Child-Pugh class	1.847 (1.035–3.296)	0.038*	1.050 (0.530–2.077)	0.890	1.100 (0.365–2.340)	0.917
ALBI	1.478 (0.805–2.712)	0.207
Tumor diameter	0.999 (0.868–1.150)	0.985
Vascular invasion	1.500 (0.888–2.534)	0.130
Single tumor	0.504 (0.301–0.842)	0.009*	0.753 (0.336–1.689)	0.491	0.817 (0.265–1.829)	0.568
Tumor capsule	0.706 (0.421–1.183)	0.186
AFP >400ng/mL	1.155 (0.691–1.930)	0.583
TB>17.1umol/L	1.026 (0.610–1.727)	0.922
Albumin<35g/L	0.950 (0.549–1.643)	0.855
Prealbumin<180mg/L	2.304 (1.367–3.881)	0.002*	2.195 (1.226–3.929)	0.008*	2.488 (1.151–4.866)	0.036*
ALT>40 U/L	0.856 (0.507–1.445)	0.560
AST>40 U/L	0.709 (0.335–1.503)	0.370
LDH>245 U/L	1.751 (1.042–2.943)	0.035*	2.136 (1.215–3.757)	0.008*	2.475 (1.183–4.677)	0.024*

Note: *The p-value is statistically significant.

Abbreviations: BMI, Body Mass Index; CAE, Collateral artery embolism; HAIC, Hepatic artery infusion chemotherapy; RALOX:Oxaliplatin plus Rituximab; ALBI, Albumin-bilirubin; TB, Total bilirubin; ALT, Alanine asninotrasferase; AST, Aspartic transaminase; AFP, Alpha-fetoprotein; LDH, Lactic dehydrogenase; HR, Hazard Ratio; CI, Confidence interval.