Table 2.
Crosstalk between MCs and other cells in DKD
| Cell Types | Mediators or Related Pathways | Effects | Reference(s) |
|---|---|---|---|
| GECs → MCs | PDGF-B/PDGFR-β signaling pathways | Promoting the proliferation of MCs and aggravating the progression of DKD | 127 |
| GECs → MCs | TGFβ1/Smad3 signaling | Mediating MCs proliferation and increased matrix protein production | 130 |
| MCs→ GECs | Integrin αvβ8/TGF-β | Inhibiting TGF-β-mediated damage in endothelial cells | 128 |
| GECs → MCs | ET-1/ETAR | Promoting MCs proliferation and ECM accumulation | 132 |
| GECs → MCs | LRG1 | Overactivating TGF-β and driving the progression of DKD. | 141 |
| MCs→ GECs | SLIT2/ROBO1 | Promoting GECs aberrant intraglomerular angiogenesis | 144 |
| MCs→ podocytes | TGFβ1/PI3K-AKT signaling pathway | Induced podocytes apoptosis | 122 |
| MCs→ podocytes | Endoplasmic reticulum (ER)-associated degradation (ERAD) | Inhibiting of ERAD-related proteins, inducing podocyte apoptosis, and promoting the progression of DKD | 198 |
| PTECs → MCs | miR-92a-1-5p | Promoting endoplasmic reticulum stress and myofibroblast cell transdifferentiation (MFT) in MCs | 151 |
| Macrophages → MCs | TGF-β1/Smad3 signaling pathway | Promoting the proliferation of MCs and the progression of DKD | 154 |
| Macrophages → MCs | NLRP3 inflammasome | Activating of NLRP3 inflammasome and inhibiting MC autophagy | 158 |