Figure 2.

Dynamic m⁶A regulatory mechanism in RNA metabolism.The m⁶A modification is orchestrated by writers (METTL3/14 complex with accessory proteins), readers (YTHDFs, HNRNPs) recognizing methylated adenosines, and erasers (FTO/ALKBH5) mediating demethylation. Writers establish m⁶A marks through catalytic methylation, readers decode these marks to regulate RNA stability, splicing, and translation, while erasers dynamically erase modifications. This tripartite system governs spatiotemporal control of RNA processing, influencing cellular metabolism and function.