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. 2025 Jul 25;21(11):4834–4850. doi: 10.7150/ijbs.105629

Figure 3.

Figure 3

Knockout of lnc-CRAT40 inhibits CRC proliferation, migration and invasion in vivo. A. Representative images of xenograft tumors from control and CRAT40 KO groups. B, C. Quantification of tumor weights and volumes. Data represent mean ± SD from five independent mice per group. D. FISH images showing lnc-CRAT40 signal in tumor tissues from control and KO groups; scale bar, 50 μm. E. qRT-PCR detection of lnc-CRAT40 expression in xenograft tumors. F. Representative images of liver metastatic nodules following intrasplenic injection. G. H&E staining of liver metastatic lesions. H. Quantification of metastatic nodules in liver tissue. Data shown as mean ± SD. H&E hematoxylin and eosin; NC, negative control; KO, knockout. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.