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. 2025 Jul 28;21(11):4979–4996. doi: 10.7150/ijbs.111449

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PLK4 expression strongly correlates with the differentiation capacity and clinical outcome of NB. A. Quantification of IHC score (NB neuroblastoma; GNB ganglioneuroblastoma; GN ganglioneuroma). RT-PCR (B) and Western blotting (C) analysis of PLK4 expression in NB tissues with different differentiation status. D. Assessment of PLK4, PHOX2B, CXCR4, and cyclin D1 expression levels and their associations in the same tumor tissues. E. Intratumoral heterogeneity was confirmed through fluorescent multiplex immunohistochemistry. F. The Kaplan-Meier survival analysis of overall survival and progress free survival for NB patients in poor-differentiated subgroup. G. Correlation analysis between PLK4 expression and PHOX2B expression, differentiation status, CXCR4 expression and bone marrow metastasis. *p < 0.05, **p < 0.01, ***p < 0.001.