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. 2025 Jul 25;21(11):4816–4833. doi: 10.7150/ijbs.107763

Figure 7.

Figure 7

JCAD activates the Wnt/β-catenin pathway by promoting an increase in downstream FZD1 expression, which mediates the EMT process and thus promotes the progression of breast cancer. A: qRT‒PCR and Western blot analysis of FZD1 mRNA and protein levels in stable FZD1-KD JCAD-OE MDA-MB-231, BT549 and LM2 cells and control cells. B: Transwell migration experiments verified that interference with FZD1 expression significantly inhibited the migration ability of JCAD-OE MDA-MB-231, BT549 and LM2 cells (10×). C: Western blot analysis of the protein levels of key molecules involved in EMT and the Wnt/β-catenin pathway in stable FZD1-KD and FZD1-shNC JCAD-OE MDA-MB-231, BT549 and LM2 cells and control cells. D: Schematic diagram of exosomal JCAD promoting the progress of breast cancer.