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. 2025 Jul 28;21(11):4961–4978. doi: 10.7150/ijbs.111224

Figure 2.

Figure 2

TERT is able to stabilize c-Myc. (A) Reciprocal Co-IP assays were performed in 8305C and A375 cells to determine the interaction between TERT and c-Myc using the indicated antibodies. (B) Reciprocal Co-IP assays were performed in 8305C and A375 cells to determine the interaction between TERT and pS62-c-Myc using the indicated antibodies. (C) Reciprocal Co-IP assays were performed in 8305C and A375 cells to determine the interaction between TERT and pT58c-Myc using the indicated antibodies. The antibody IgG was used as negative control, and the co-immunoprecipitation is representative of three independently preformed experiments. (D) 8305C and A375 cells were pretreated with 25 μM MG132 or DMSO for four hours and treated with si-TERT. The western blotting analysis was then used to evaluate TERT, BRAF and c-Myc expression. GAPDH was used as control.