Table 5.
Prediction of live birth, clinical pregnancy, and ongoing pregnancy by the initial level and rate of increase in serum β-hCG levels between patients after PGT and non-PGT
| Variables | Initial serum β-hCG levels, PGT group (n = 1698) | Initial serum β-hCG levels, Non PGT group (n = 1830) | ||||
|---|---|---|---|---|---|---|
| Clinical pregnancy | Ongoing pregnancy | Live birth | Clinical pregnancy | Ongoing pregnancy | Live birth | |
| Threshold value (IU/L) | 71.5 | 101.50 | 122.5 | 100.5 | 121.5 | 130.5 |
| Sensitivity (%) | 89.3 | 80.0 | 70.1 | 81.5 | 75.5 | 71.7 |
| Specificity (%) | 72.5 | 60.6 | 60.1 | 76.0 | 61.0 | 61.6 |
| PPV (%) | 96.7 | 82.2 | 84.7 | 96.5 | 63.1 | 82.2 |
| NPV | 42.5 | 29.1 | 38.9 | 33.5 | 72.8 | 46.9 |
| AUC | 0.870 | 0.761 | 0,724 | 70.1 | 0.741 | 0,726 |
| p-value | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
| Increase rate of β-hCGlevels (fold) PGT group (n = 1698) |
Increase rate of β-hCGlevels (fold) Non PGT group (n = 1830) |
|||||
|---|---|---|---|---|---|---|
| Threshold value (Fold) | 1.98 | 2.47 | 2.33 | 2.11 | 2.5 | 2.31 |
| Sensitivity (%) | 90.6 | 58.3 | 73.5 | 83.6 | 52.0 | 73.6 |
| Specificity (%) | 74.3 | 45.1 | 59.9 | 72.5 | 47.9 | 52.9 |
| PPV (%) | 97.0 | 70.0 | 85.4 | 96.1 | 65.0 | 79.4 |
| NPV (%) | 46.3 | 98.0 | 41.4 | 35.1 | 98.6 | 44.9 |
| AUC | 0.869 | 0.535 | 0.705 | 0.831 | 0.542 | 0.662 |
| p-value | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Initial β-HCG levels were measured on day 9 post-blastocyst transfer