Table 2.
Use of hormonal contraception during follow-up among cases and controls
| Overall | Cases | Controls | p | |
|---|---|---|---|---|
| REFERENCE GROUP: no use of hormonal contraception | 11136 (68·6) | 2384 (76·9) | 8752 (66·6) | < 0·001 |
| Any hormonal contraception use | 5107 (31·4) | 716 (23.1) | 4391 (33.4) | < 0·001 |
| GROUP: combined oral contraceptives, EE | 2702 (16·6) | 438 (14·1) | 2264 (17·2) | < 0·001 |
| Levonorgestrel and ethinylestradiol, fixed preparations | 67 (0·4) | 8 (0·3) | 59 (0·4) | |
| Desogestrel and ethinylestradiol, fixed preparations | 328 (2·0) | 62 (2·0) | 266 (2·0) | |
| Gestodene and ethinylestradiol, fixed preparations | 555 (3·4) | 65 (2·1) | 490 (3·7) | |
| Drospirenone and ethinylestradiol, fixed preparations | 1279 (7·9) | 212 (6·8) | 1067 (8·1) | |
| Dienogest and ethinylestradiol, fixed preparations | 104 (0·6) | 19 (0·6) | 85 (0·6) | |
| Levonorgestrel and ethinylestradiol, sequential preparations | < 5 (0·0) | < 5 (0·0) | < 5 (0·0) | |
| Cyproterone and ethinylestradiol, fixed preparations* | 366 (2·3) | 71 (2·3) | 295 (2·2) | |
| GROUP: combined oral contraceptives, E2 | 376 (2·3) | 41 (1·3) | 335 (2·5) | < 0·001 |
| Nomegestrol and oestradiol, fixed preparations | 178 (1·1) | 18 (0·6) | 160 (1·2) | |
| Dienogest and oestradiol, sequential preparations | 198 (1·2) | 23 (0·7) | 175 (1·3) | |
| GROUP: progestin-only oral contraceptives | 1332 (8·2) | 130 (4·2) | 1202 (9·1) | < 0·001 |
| Norethisterone | 101 (0·6) | 15 (0·5) | 86 (0·7) | |
| Desogestrel | 1217 (7·5) | 111 (3·6) | 1106 (8·4) | |
| Drospirenone | 14 (0·1) | < 5 (0·1) | 10 (0·1) | |
| GROUP: hormonal intrauterine device; Plastic IUD with levonorgestrel | 219 (1·3) | 32 (1·0) | 187 (1·4) | < 0·001 |
| GROUP: vaginal ring; Etonogestrel and ethinylestradiol | 312 (1·9) | 48 (1·5) | 264 (2·0) | < 0·001 |
| GROUP: contraceptive patch; Norelgestromin and ethinylestradiol | 41 (0·3) | 8 (0·3) | 33 (0·3) | < 0·001 |
| GROUP: contraceptive implant | 125 (0·8) | 19 (0·6) | 106 (0·8) | < 0·001 |
| Etonogestrel | 51 (0·3) | 10 (0·3) | 41 (0·3) | |
| Levonorgestrel | 74 (0·5) | 9 (0·3) | 65 (0·5) |
IUD = intrauterine device. *Due to the classification of ATC code G03HB01 (cyproterone and oestrogens), the combined oral contraceptives with cyproterone and ethinylestradiol includes around 14% products in which cyproterone was combined with natural oestradiol, not ethinylestradiol