Table 1.
Characteristics of women in the study population
| Variables | Non-preeclampsia | Preeclampsia | P value |
|---|---|---|---|
| N = 1955 | N = 108 | ||
| Maternal age | 32 (27, 34) | 33 (27, 36.8) | 0.063 |
| Height (cm) | 160 (163, 166) | 162 (160, 165) | 0.246 |
| Admission weight (kg) | 75 (68.5, 83) | 84.5 (74, 97) | < 0.001 |
| Maternal weight gain (kg) | 15 (11, 19) | 14 (10, 19.8) | 0.315 |
| Pre-pregnancy weight (kg) | 60 (54, 67.5) | 71 (59.5, 81) | < 0.001 |
| BMI | 22.58 (20.37, 25.16) | 27.00 (22.84, 31.20) | < 0.001 |
| SBP (mmHg) | 121 (120, 122) | 122 (120, 130) | < 0.001 |
| DBP (mmHg) | 70 (66, 75) | 75 (68, 84.7) | < 0.001 |
| MAP | 86.67 (86.47, 93.33) | 92.67 (85.33, 98.00) | < 0.001 |
| GA at screening PlGF (wk. + d) | 20.0 (16.1, 26.1) | 22.2 (16.2, 27.3) | 0.404 |
| PlGF (pg./mL) | 103 (74.2, 157) | 76.5 (52.5, 112) | < 0.001 |
| sFlt-1 (pg./mL) | 1464 (1240, 1750) | 1602 (1278, 1847) | 0.048 |
| sFlt-1/PlGF ratio | 14.1 (9.38, 20.0) | 22.8 (13.0, 33.0) | < 0.001 |
| Nulliparity (Yes) | 733 (37.5) | 47 (43.5) | 0.209 |
| Type 1 or type 2 diabetes (Yes) | 367 (18.8) | 35 (32.4) | < 0.001 |
| Pregnancy with hypothyroidism (Yes) | 119 (6.09) | 8 (7.41) | 0.578 |
| Pregnancy with hyperthyroidism (Yes) | 5 (0.26) | 0 (0.00) | 1.000 |
| History of adverse pregnancy (Yes) | 102 (5.22) | 19 (17.6) | < 0.001 |
| Multifetal gestation (Yes) | 71 (3.63) | 6 (5.56) | 0.305 |
| Conception by ART (Yes) | 143 (7.31) | 9 (8.33) | 0.693 |
| Family history of PE (Yes) | 6 (0.31) | 9 (8.33) | < 0.001 |
| History of PE (Yes) | 4 (0.20) | 8 (7.41) | < 0.001 |
| Renal disease (Yes) | 2 (0.10) | 7 (6.48) | < 0.001 |
| Chronic hypertension (Yes) | 21 (1.07) | 21 (19.4) | < 0.001 |
| Autoimmune disease (Yes) | 21 (1.07) | 17 (15.7) | < 0.001 |
| PPWPA (Yes) | 2 (0.10) | 0 (0.00) | 1.000 |
| Prior pregnancy with FGR (Yes) | 2 (0.10) | 0 (0.00) | 1.000 |
| Aspirin (Yes) | 28 (1.43) | 15 (13.9) | < 0.001 |
| Previous history of stillbirth (Yes) | 15 (0.77) | 1 (0.93) | 0.578 |
| PCOS (Yes) | 26 (1.33) | 14 (13.0) | < 0.001 |
BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, MAP mean arterial pressure, GA gestational age, PlGF placental growth factor, sFlt-1 soluble fms-like tyrosine kinase-1, ART assisted reproductive technique, FGR fetal growth restriction, PCOS polycystic ovary syndrome, PPWPA prior pregnancy with placental abruption