Table 1.
Description of the main study cohort
| Astrocytoma (n = 77) | Oligodendroglioma (n = 60) | P value | |
|---|---|---|---|
| Epidemiological and clinical parameters | |||
| Gender n (%) | Male 48 (62), Female 29 (38) | Male 36 (60), Female 24 (40) | 0.8601a |
| Age at diagnosis median (range) in years | 35 (18–62) | 43 (16–70) | 0.0006b |
| Primary tumor n (%) | 63 (83) | 40 (67) | 0.0430a |
| KPS prior to surgery median (range) | 100 (70–100) | 100 (20–100) | 0.2650b |
| Extent of resection n (%) | 0.6901c | ||
| Total | 16 (27) | 11 (25) | |
| > 90% | 12 (20) | 6 (14) | |
| < 90% | 9 (15) | 10 (23) | |
| Biopsy only | 22 (37) | 17 (39) | |
| Treatment n (%) | 0.3617c | ||
| Radiation + Chemotherapy | 53 (69) | 36 (62) | |
| Resection only | 13 (17) | 7 (12) | |
| Radiation only | 4 (5) | 7 (12) | |
| Chemotherapy only | 2 (3) | 4 (7) | |
| Missing data or no treatment | 5 (6) | 4 (7) | |
| Observation prior to resection n (%) |
na/0 days 59 (77), 18 (23) median 2257 days (2–8115 days) |
na/0 days 41 (68), 19 (32) median 1787 days (21–5619 days) |
|
| Molecular parameters | |||
| V11b4 HD brain tumor classifier methylation class n (%) | Glioma, IDH mutant 77 (100) | Glioma, IDH mutant 58 (97), missing 2 (3) | |
| V11b4 HD brain tumor classifier calibrated score median (range) | 0.99 (0.38–0.99) | 0.99 (0.42–0.99) | 0.6788b |
| V11b4 HD brain tumor classifier methylation subclass n (%) | Astrocytoma 62 (81), high-grade astrocytoma 15 (19) | Oligodendroglioma 1p/19q-codeleted 56 (93), astrocytoma 2 (3), missing 2 (3) | |
| MGMT promoter methylation status n (%) | Unmethylated 17 (22), Methylated 57 (74), missing 3 (4) | Unmethylated 4 (7), Methylated 54 (90), missing 2 (3) | 0.0156a |
| Histological parameters | |||
| WHO CNS grade 2 | 12 (16) | 21 (35) | |
| WHO CNS grade 3 | 39 (51) | 39 (65) | |
| WHO CNS grade 4 | 26 (34) | na |
Epidemiological, clinical and molecular characteristics
P values with numbers in superscript indicating statistical test: aFisher’s exact test, bWilcoxon, cPearson; within “Extent of resection” and “Treatment”, respectively, all categories were considered together for p value computation
P values highlighted in italic indicate significance