Table 3.

Comparison of TXNIP levels and metabolic parameters across PCOS groups with different BMI and control

Parameter	Ctrl. (n = 102)	OB-PCOS (n = 21)	OW-PCOS (n = 38)	P-value
Age (years)	24.62 ± 4.67	25.52 ± 4.09	24.84 ± 4.71	0.739
AMH (ng/mL)	8.13 ± 3.17	7.28 ± 3.23	7.44 ± 3.41	0.369
HCY (µmol/L)	11.83 ± 3.75	12.04 ± 3.86	11.31 ± 3.59	0.702
HOMA-IR	1.60 ± 1.14	4.33 ± 3.04	2.75 ± 1.73	< 0.001
Fins (mU/L)	7.32 ± 4.68	18.46 ± 11.53	12.13 ± 6.91	< 0.001
FBG (mmol/L)	4.84 ± 0.39	5.16 ± 0.69	4.95 ± 0.54	0.017
CRP (mg/L)	1.86 ± 2.62	3.61 ± 2.97	2.52 ± 2.67	0.020
TG (mmol/L)	0.98 ± 0.55	1.85 ± 1.04	1.43 ± 0.76	< 0.001
HDL (mmol/L)	1.60 ± 0.36	1.13 ± 0.23	1.30 ± 0.26	< 0.001
LDL (mmol/L)	2.58 ± 0.72	2.91 ± 0.70	2.76 ± 0.78	0.103
TC (mmol/L)	4.74 ± 0.84	4.92 ± 0.84	4.70 ± 0.94	0.628
TXNIP (ng/mL)	0.30 ± 0.07	0.38 ± 0.11	0.33 ± 0.11	< 0.001

Note: P < 0.05 indicates statistical significance. Data are expressed as mean ± standard deviation

Abbreviations: AMH Anti-Müllerian hormone, HCY Homocysteine, HOMA-IR Homeostatic Model Assessment Index, Fins Fasting insulin, FBG Fasting blood glucose, CRP C-reactive protein, TG Triglycerides, HDL High-density lipoprotein, LDL Low-density lipoprotein, TC Total cholesterol, TXNIP Thioredoxin-interacting protein, OB-PCOS Obese PCOS group, OW-PCOS Overweight PCOS group, CTRL Control group