Table 3.
Global health, functional, symptom, by time since diagnosis
| Characteristics | Baseline | 6 months | 1 year | 2 years | 3 years | 4 years |
|---|---|---|---|---|---|---|
| (N = 2,749) | (N = 1,283) | (N = 2,449) | (N = 2,755) | (N = 1,975) | (N = 713) | |
| Global health status/quality of life | ||||||
| Global health status/quality of life | 55.62 (21.53) | 52.93 (20.82) | 59.21 (19.71) | 62.23 (19.79) | 65.71 (20.45) | 68.21 (18.74) |
| Functional scales | ||||||
| Physical functioning | 84.96 (11.97) | 72.42 (18.26) | 79.10 (14.14) | 81.93 (13.11) | 83.91 (12.32) | 85.31 (11.59) |
| Cognitive functioning | 85.47 (15.72) | 78.11 (18.26) | 78.25 (17.77) | 78.31 (18.17) | 78.71 (18.00) | 79.73 (17.08) |
| Emotional functioning | 69.26 (22.47) | 72.01 (20.30) | 74.47 (19.57) | 75.50 (19.49) | 76.88 (18.94) | 77.98 (19.00) |
| Social functioning | 77.56 (24.16) | 68.61 (24.95) | 75.59 (23.29) | 78.45 (22.89) | 81.72 (21.59) | 83.90 (21.13) |
| Role functioning | 91.89 (14.78) | 74.51 (23.82) | 80.16 (19.71) | 82.83 (18.91) | 85.35 (17.56) | 86.43 (17.33) |
| Symptoms | ||||||
| Fatigue | 31.13 (20.69) | 41.75 (22.50) | 36.41 (20.15) | 35.41 (19.93) | 33.94 (19.81) | 32.71 (18.44) |
| Nausea and vomiting | 5.75 (10.61) | 11.99 (15.03) | 6.12 (10.60) | 5.89 (10.73) | 5.05 (9.48) | 5.45 (9.90) |
| Pain | 14.19 (16.80) | 27.30 (21.81) | 24.81 (19.77) | 20.50 (18.56) | 17.03 (16.41) | 16.67 (15.83) |
| Dyspnea | 12.92 (19.31) | 24.11 (25.63) | 15.68 (20.87) | 14.06 (19.30) | 13.28 (18.67) | 13.92 (18.51) |
| Insomnia | 28.56 (27.58) | 41.06 (29.62) | 38.64 (29.29) | 35.95 (28.39) | 34.94 (28.68) | 34.05 (27.62) |
| Appetite loss | 14.73 (20.37) | 24.54 (27.97) | 14.78 (21.04) | 11.60 (19.10) | 9.96 (17.75) | 9.54 (17.18) |
| Constipation | 15.34 (22.91) | 18.76 (25.84) | 16.14 (23.92) | 17.58 (24.26) | 17.87 (23.91) | 18.04 (23.99) |
| Diarrhea | 11.65 (19.20) | 14.86 (22.91) | 7.47 (16.00) | 6.82 (15.06) | 6.78 (14.55) | 7.16 (14.54) |
| Financial problem | 14.77 (23.72) | 20.18 (26.50) | 16.58 (23.93) | 15.05 (22.94) | 13.39 (22.00) | 13.57 (22.78) |
| Breast cancer-specific functioning | ||||||
| Body image | 83.00 (19.81) | 61.60 (28.40) | 68.84 (26.34) | 70.78 (25.54) | 72.98 (24.35) | 73.80 (24.55) |
| Sexual functioning | 15.74 (19.94) | 10.31 (16.82) | 12.79 (18.54) | 13.44 (19.42) | 12.77 (18.83) | 14.18 (20.92) |
| Sexual enjoyment | 26.66 (26.44) | 11.18 (19.76) | 13.37 (21.42) | 14.07 (21.73) | 12.90 (20.64) | 14.07 (22.48) |
| Future perspective | 48.62 (30.30) | 41.46 (28.52) | 45.78 (28.66) | 49.51 (27.81) | 53.41 (27.12) | 54.20 (26.36) |
| Breast cancer-specific symptoms | ||||||
| Systemic therapy side effects | 17.26 (13.75) | 30.01 (19.09) | 20.70 (14.45) | 21.08 (14.31) | 20.06 (14.37) | 20.22 (14.13) |
| Upset by hair loss | 25.03 (29.81) | 50.10 (37.07) | 38.58 (34.27) | 41.31 (33.41) | 42.88 (32.36) | 42.95 (31.45) |
| Arm symptoms | 18.77 (19.30) | 30.69 (23.63) | 31.94 (24.46) | 26.63 (22.72) | 22.25 (20.19) | 20.79 (19.17) |
| Breast symptoms | 14.40 (16.04) | 17.37 (16.03) | 21.45 (17.07) | 17.10 (14.91) | 14.23 (13.68) | 12.72 (12.60) |
| Fear of recurrence | 13.51 (7.22) | 14.74 (6.81) | 14.44 (6.81) | 13.83 (6.80) | 13.16 (6.79) | 12.89 (6.52) |
| Depression | 4.90 (5.00) | 5.68 (4.93) | 4.75 (4.56) | 4.51 (4.49) | 4.16 (4.22) | 3.90 (4.11) |
| Menopause symptoms | 8.49 (6.97) | 12.15 (7.47) | 12.09 (7.46) | 12.02 (7.51) | 11.53 (7.36) | 10.98 (7.04) |
| Nutrition and eating behavior | 28.34 (13.39) | 25.37 (8.78) | 25.82 (8.47) | 26.58 (7.60) | 27.15 (7.44) | 27.79 (6.65) |
| Financial Toxicity | 25.14 (7.62) | 25.14 (8.10) | 26.17 (7.67) | 26.36 (7.83) | 26.99 (7.72) | 27.40 (7.81) |
| Cognitive impairment | ||||||
| Perceived cognitive impairments | 63.60 (9.77) | 60.64 (11.23) | 60.22 (11.36) | 59.71 (12.21) | 60.31 (11.27) | 60.57 (11.20) |
| Impact on quality of life | 10.94 (4.26) | 11.51 (3.97) | 11.96 (3.72) | 12.12 (3.70) | 12.43 (3.60) | 12.49 (3.67) |
| Comments from others | 15.49 (1.42) | 15.44 (1.37) | 15.40 (1.53) | 15.33 (1.65) | 15.44 (1.46) | 15.54 (1.26) |
| Perceived cognitive abilities | 18.19 (6.67) | 17.09 (5.78) | 16.86 (5.94) | 16.85 (5.91) | 17.35 (5.82) | 17.47 (5.76) |
| Mental adjustment | ||||||
| Helpless/Hopeless | 12.57 (3.84) | 12.89 (3.92) | 12.55 (3.95) | 12.41 (3.88) | 12.11 (3.70) | 11.95 (3.69) |
| Anxious Preoccupation | 20.71 (4.98) | 19.76 (4.65) | 19.13 (4.61) | 18.55 (4.69) | 18.05 (4.62) | 17.70 (4.64) |
| Fighting Spirit | 11.74 (2.00) | 11.77 (1.88) | 11.70 (1.93) | 11.67 (1.89) | 11.67 (1.97) | 11.71 (1.98) |
| Cognitive Avoidance | 10.35 (2.43) | 10.28 (2.42) | 10.31 (2.38) | 10.39 (2.44) | 10.42 (2.50) | 10.55 (2.45) |
| Fatalism | 13.96 (2.58) | 14.12 (2.48) | 14.33 (2.50) | 14.41 (2.47) | 14.54 (2.58) | 14.59 (2.56) |
Values are expressed as mean (SD); the unique numbers were 992, 1966, 1805, 1414, and 560 at 6 months, 1 year, 2 years, 3 years, and 4 years after diagnosis, respectively