Table 2.

Number and type of events required in the algorithms used to identify women with multiple sclerosis

Algorithm		MS14	MS2		MS35		MS46		MS56
Linkage			AND3		AND3		OR3
Number of events required Type of event possible		≥1	≥1	≥1	≥1	≥2	≥1	≥2	≥2
MS Diagnoses1	Inpatient	✔	✔	✔	✔	✔	✔		✔
	Outpatient/ Hospital unspecified	✔	✔	✔	✔	✔		✔	✔
	Primary care	✔	✔	✔	✔	✔		✔	✔
DMT2 prescriptions	MS-specific DMT	✔	✔	✔	✔	✔
	Non-specific MS DMT			✔		✔

The table reads as follows: For the algorithm MS2, at least 2 events are required: at least 1 event among MS diagnoses and MS-specific DMTs AND at least one event among MS diagnoses, MS-specific DMTs and non-specific MS DMTs

¹Diagnosis codes as defined in Table 2

²DMT as defined in Table 2

³Diagnoses occurring at least 30 days apart

⁴Used by Foulon et al., 2017

⁵Based on Culpepper et al. 2019

⁶Most accurate algorithms according to Capkun et al. 2015