Table 3.

Associations between current HC use and depression diagnosis (Care register for health care and register of primary health care visits)

		Model 1		Model 2		Model 3
		Odds Ratio	95% CI	Odds Ratio	95% CI	Odds Ratio	95% CI
HC use = one redeemed prescription
HC use	No HC	Reference		Reference		Reference
	Current HC	0.86	0.83, 0.89	0.90	0.87, 0.94	0.92	0.87, 0.96
	CHC	0.79	0.76, 0.82	0.86	0.82, 0.89	0.88	0.83, 0.92
	EE containing CHCs	0.78	0.75, 0.81	0.86	0.82, 0.90	0.88	0.83, 0.93
	Estradiol containing CHCs	0.82	0.77, 0.87	0.84	0.78, 0.91	0.85	0.78, 0.93
	Progestin-only	1.08	1.02, 1.13	1.04	0.97, 1.11	1.02	0.95, 1.09
HC use = two redeemed prescriptions
HC use	No HC	Reference		Reference		Reference
	Current HC	0.85	0.82, 0.88	0.88	0.84, 0.92	0.90	0.85, 0.95
	CHC	0.79	0.76, 0.82	0.84	0.80, 0.88	0.86	0.81, 0.91
	EE containing CHCs	0.79	0.75, 0.83	0.85	0.80, 0.90	0.87	0.82, 0.93
	Estradiol containing CHCs	0.79	0.73, 0.86	0.81	0.74, 0.89	0.82	0.75, 0.91
	Progestin-only	1.04	0.97, 1.11	1.01	0.93, 1.10	1.02	0.93, 1.11

HC use defined as one redeemed prescription (upper part) or two redeemed prescriptions (bottom part). model 1 is univariable; model 2 is controlled for marital status, socioeconomic status, education, recent delivery and recent psychiatric hospitalization; model 3 is model 2 further controlled for chronic diseases*, use of psychiatric medications (excluding antidepressants) and former use of HC

^*Diabetes, multiple sclerosis, epilepsy, severe psychiatric disorders, connective tissue diseases, ulcerative colitis or Crohn’s disease, cancer

CHC combined hormonal contraception, EE ethinylestradiol, HC hormonal contraception