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. 2025 Jun 6;312(3):849–856. doi: 10.1007/s00404-025-08068-6

Table 2.

Fetal and neonatal outcomes

Variable Singleton (N = 161) First twin (N = 77) Second twin (N = 77) p
Outcome
 Livebirth 156 (96.9%) 75 (97.4%) 77 (100%) 0.728; 0.295*
 Neonatal Death 1 (0.6%) 1 (1.3%) 0
Stillbirth 4 (2.5%) 1 (1.3%) 0
Arterial cord blood pH 7.30 (0.12) 7.31 (0.07) 7.29 (0.11) 0.940; 0.687*
Arterial cord blood pH < 7 0 1 (0.01%) 0 0.106; 1*
Venous cord blood pH 7.33 (0.07) 7.35 (0.05) 7.35 (0.03) 0.096; 0.436*
Apgar test score 5` 10 (1) 10 (0) 10 (1) 0.069; 0.294*
Birthweight, grams ** 2,317.2 (445.8) 2,160.4 (480.7) 2,538.4 (881.4) 0.171; 0.026*
Birthweight, centile 30 (58) 30 (50.5) 15 (33) 0.999; 0.005*
Birthweight < 10th centile 48 (30.6%) 19 (25%) 32 (41.6%) 0.379; 0.097*
nICU admission 28 (17.8%) 6 (7.8%) 10 (13.0%) 0.041; 0.345*
nICU admission time, days 15.0 (19) 7.5 (5) 7.0 (5) 0.174; 0.029*
Neonatal complications 47 (29.2%) 23 (30.0%) 21 (27.3%) 0.890; 0.790
Ventilation 36 (22.4%) 13 (16.9%) 8 (10.4%) 0.300; 0.024*
 Intubation 16 (9.9%) 2 (2.6%) 2 (2.6%) 0.060; 0.058*
 Intubation time, days 2.0 (2) 1 (66) 3.5 (1) 0.995; 0.659*
 CPAP 30 (18.6%) 8 (10.4%) 6 (7.8%) 0.099; 0.029*
 CPAP time, days 0 (1) 2 (4) 1.75 (2) 0.001; 0.012*
RDS 36 (22.4%) 12 (15.6%) 7 (9.1%) 0.204; 0.013*
Phototherapy 29 (18.0%) 12 (15.6%) 16 (20.8%) 0.602; 0.674
Phototherapy, days 2 (2) 1 (1) 1.5 (1) 0.389; 0.789*
Intraventricular hemorrhage 2 (1.2%) 2 (2.6%) 0 0.464; < 0.001*
Anemia 7 (4.3%) 4 (5.2%) 2 (2.6%) 0.790; 0.492*
Blood transfusion 4 (2.5%) 2 (2.6%) 2 (2.6%) 0.976; 0.982*
Necrotizing enterocolitis 4 (2.5%) 1 (1.3%) 0 0.550; < 0.001*
Retinopathy 6 (3.7%) 1 (1.3%) 0 0.316; < 0.001*
Sepsis 5 (3.1%) 2 (2.6%) 3 (3.9%) 0.812; 0.779*

Values are median (Interquartile range) or absolute frequency (relative frequency). Statistically significant comparisons are represented in bold

nICU neonatal intensive care unit, IMV Invasive Mechanical Ventilation. RDS Respiratory Distress Syndrome. *Comparing second twin with singleton with Bonferroni correction. **Variables reported as means (standard deviation)